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Article
Open AccessFunctional epigenomics approach to identify methylated candidate tumour suppressor genes in renal cell carcinoma
Promoter region hypermethylation and transcriptional silencing is a frequent cause of tumour suppressor gene (TSG) inactivation in many human cancers. Previously, to identify candidate epigenetically inactivat...
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Article
Open AccessEpigenetic alteration at the DLK1-GTL2 imprinted domain in human neoplasia: analysis of neuroblastoma, phaeochromocytoma and Wilms' tumour
Epigenetic alterations in the 11p15.5 imprinted gene cluster are frequent in human cancers and are associated with disordered imprinting of insulin-like growth factor (IGF)2 and H19. Recently, an imprinted gene c...
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Article
Open AccessEpigenetic inactivation of SLIT3 and SLIT1 genes in human cancers
In Drosophila, the Slit gene product, a secreted glycoprotein, acts as a midline repellent to guide axonal development during embryogenesis. Three human Slit gene orthologues have been characterised and recent...
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Article
Open AccessInvestigation of the role of SDHB inactivation in sporadic phaeochromocytoma and neuroblastoma
Germline mutations in the succinate dehydrogenase (SDH) (mitochondrial respiratory chain complex II) subunit B gene, SDHB, cause susceptibility to head and neck paraganglioma and phaeochromocytoma. Previously, we...
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Article
Open AccessSLIT2 promoter methylation analysis in neuroblastoma, Wilms' tumour and renal cell carcinoma
The 3p21.3 RASSF1A tumour suppressor gene (TSG) provides a paradigm for TSGs inactivated by promoter methylation rather than somatic mutations. Recently, we identified frequent promoter methylation without somati...
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Article
Ophthalmological screening for von Hippel-Lindau disease
Forty seven individuals (from 16 kindreds) without prior evidence of retinal hae-mangiomas underwent full ophthalmological assessment as part of a comprehensive screening programme for Von Hippel-Lindau diseas...
