16 Result(s)
within
E. P. Paschalis
Orthopedics
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Article
Vibrational spectroscopic techniques to assess bone quality
Although musculoskeletal diseases such as osteoporosis are diagnosed and treatment outcome is evaluated based mainly on routine clinical outcomes of bone mineral density (BMD) by DXA and biochemical markers, i...
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Article
Fourier Transform Infrared Spectroscopic Characterization of Mineralizing Type I Collagen Enzymatic Trivalent Cross-Links
The most abundant protein of bone’s organic matrix is collagen. One of its most important properties is its cross-linking pattern, which is responsible for the fibrillar matrices’ mechanical properties such as...
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Article
Effects of long-term alendronate treatment on postmenopausal osteoporosis bone material properties
Raman microspectroscopic analysis of iliac crest from patients that were treated with alendronate (ALN) for 10 years revealed minimal, transient alterations in bone material properties confined to actively for...
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Article
Vibrational Spectroscopic Imaging for the Evaluation of Matrix and Mineral Chemistry
Metabolic bone diseases manifesting fragility fractures (such as osteoporosis) are routinely diagnosed based on bone mineral density (BMD) measurements, and the effect of various therapies also evaluated based...
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Article
Bone quality of the newest bone formed after two years of teriparatide therapy in patients who were previously treatment-naïve or on long-term alendronate therapy
The results of the present study, involving analysis of biopsies from patients who received teriparatide for 2 years and were previously either treatment-naïve or on long-term alendronate therapy, suggest that...
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Article
Effects of 3 years treatment with once-yearly zoledronic acid on the kinetics of bone matrix maturation in osteoporotic patients
Once-yearly administration of intravenous zoledronic acid for 3 years in humans affects the kinetics of matrix filling in by mineral, independent of bone turnover.
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Article
Fourier transform infrared analysis and bone
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Article
Collagen Cross-Linking Influences Osteoblastic Differentiation
Osteoblasts synthesize collagen matrix, which itself regulates the differentiation of precursor cells into mature osteoblasts. They express lysyl oxidase (LOX), which is involved in the collagen cross-linking ...
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Article
Complementary Information on In Vitro Conversion of Amorphous (Precursor) Calcium Phosphate to Hydroxyapatite from Raman Microspectroscopy and Wide-Angle X-Ray Scattering
In addition to mechanical functions, bones have an essential role in metabolic activity as mineral reservoirs that are able to absorb and release ions. Bioapatite, considered the major component in the mineral...
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Article
Osteoblast-Mediated Mineral Deposition in Culture is Dependent on Surface Microtopography
Osteoblast phenotypic expression in monolayer culture depends on surface microtopography. Here we tested the hypothesis that mineralized bone nodule formation in response to osteotropic agents such as bone mor...
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Article
Optimal Methods for Processing Mineralized Tissues for Fourier Transform Infrared Microspectroscopy
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Article
FTIR Microspectroscopic Analysis of Human Iliac Crest Biopsies from Untreated Osteoporotic Bone
Historically, osteoporosis has been defined as a disease in which there is ``too little bone, but what there is, is normal.'' As a result of research design and sample selection limitations, published data co...
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Article
FTIR Microspectroscopic Analysis of Normal Human Cortical and Trabecular Bone
Fourier transform infrared microspectroscopy (FTIRM) has been used to study the changes in mineral and matrix content and composition in replicate biopsies of nonosteoporotic human cortical and trabecular bon...
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Article
FTIR microspectroscopic analysis of human osteonal bone
Fourier Transform Infrared Microspectroscopy (FTIRM) has been used to study the changes in mineral and matrix content and composition in replicate biopsies of non-osteoporotic human osteonal bone. Spectral map...
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Article
Fourier transform infrared spectroscopy of the solution-mediated conversion of amorphous calcium phosphate to hydroxyapatite: New correlations between X-ray diffraction and infrared data
Fourier Transform infrared spectroscopic analysis of maturing, poorly crystalline hydroxyapatite (HA) formed from the conversion of amorphous calcium phosphate (ACP) at constant pH or variable pH show only sub...
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Chapter
The Characterization of Biologically Important Apatite Surfaces Using the Dual Constant Composition and Ftir Microscopy Techniques
The calcium phosphates are among the most important salts of orthophosphoric acid. They include a group known as apatites, derived from the Greek word απατω, which means to deceive. In the eighteenth century, ...
