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Article
Ketamine enhances structural plasticity in mouse mesencephalic and human iPSC-derived dopaminergic neurons via AMPAR-driven BDNF and mTOR signaling
Among neurobiological mechanisms underlying antidepressant properties of ketamine, structural remodeling of prefrontal and hippocampal neurons has been proposed as critical. The suggested mechanism involves do...
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Article
Neuroimaging as endpoints in clinical trials: Are we there yet? Perspective from the first Provence workshop
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Article
Time-dependent induction of anxiogenic-like effects after central infusion of urocortin or corticotropin-releasing factor in the rat
Rationale: Corticotropin-releasing factor (CRF) and urocortin (Ucn) belong to the CRF-related family, share a high degree of structural homology and bind to CRF receptors. However, compared with CRF, Ucn was show...
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Article
Highly controlled gene expression using combinations of a tissue-specific promoter, recombinant adenovirus and a tetracycline-regulatable transcription factor
Controllable gene expression is a desirable feature both in gene therapy protocols and for the study of gene function in animals and plants. We have exploited the modular character of the tetracycline (tc)-reg...
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Article
Changes in glucocorticoid receptor immunoreactivity after adrenalectomy and corticosterone treatment in the rat testis
The distribution of glucocorticoid receptor (GR) in the rat testis was investigated by means of immunocytochemistry (IR) and computer-assisted image analysis. A monoclonal antibody against rat liver GR showed ...
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Chapter and Conference Paper
Effects of Transient Global Cerebral Ischemia on Peptide Neuronal Populations in Different Brain Regions and on Behavioral Performances in Rats
It is known that neurons are more sensitive to ischemic damage than oligodendroglia, astroglia, and endothelial cells [7]. Furthermore, the neuronal populations in various brain regions show a differential vul...
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Chapter
Regeneration in the Central Nervous System: Concepts and Facts
In many years, based on Cajal’s statement “… nerve paths are fixed, ended, immutable. Everything may die, nothing may be regenerated…” (Ramon y Cajal 1928) it has been assumed that the central nervous system (...
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Chapter
Aspects on the Integrative Capabilities of the Central Nervous System: Evidence for ‘Volume Transmission’ and its Possible Relevance for Receptor-Receptor Interactions
The hypothesis is introduced that the central nervous system (CNS) is endowed with the capability of handling information, not only based on the topological organization of its elements and the patterns of imp...
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Chapter
Aspects on the Integrative Capabilities of the Central Nervous System: Evidence for ‘Volume Transmission’ and its Possible Relevance for Receptor-Receptor Interactions
The hypothesis is introduced that the central nervous system (CNS) is endowed with the capability of handling information, not only based on the topological organization of its elements and the patterns of imp...
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Article
Disinhibitory effects of buspirone and low doses of sulpiride and haloperidol in two experimental anxiety models in rats: Possible role of dopamine
Low doses of buspirone, haloperidol and sulpiride were compared with diazepam in two experimental models of anxiety in rats. In a conflict test, 0.6 and 1.2 mg/kg buspirone, 0.05 and 0.10 mg/kg haloperidol and...
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Chapter
Studies on the Involvement of Polyamines for the Trophic Actions of the Ganglioside GM1 in Mechanically and 6-hydroxydopamine Lesioned Rats. Evidence for a Permissive Role of Putrescine
In 1983 we were able to demonstrate for the first time that chronic ganglioside GM1 treatment in mechanically lesioned rats could partly counteract the retrograde cell body degeneration taking place in the cen...
