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Open AccessEffects of intra-accumbal or intra-prefrontal cortex microinjections of adenosine 2A receptor ligands on responses to cocaine reward and seeking in rats
Many studies indicated that adenosine via its A2A receptors influences the behavioral effects of cocaine by modulating dopamine neurotransmission. The hypothesis was tested that A2A receptors in the nucleus accum...
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Article
Evidence for the existence of dopamine d2-oxytocin receptor heteromers in the ventral and dorsal striatum with facilitatory receptor–receptor interactions
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Article
The dopamine stabilizers ACR16 and (−)-OSU6162 display nanomolar affinities at the σ-1 receptor
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Article
The FGF-2/FGFRs neurotrophic system promotes neurogenesis in the adult brain
Neurogenesis occurs in two regions of the adult brain, namely, the subventricular zone (SVZ) throughout the wall of the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus (DG) in hippocampal...
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Article
Common key-signals in learning and neurodegeneration: focus on excito-amino acids, β-amyloid peptides and α-synuclein
In this paper a hypothesis that some special signals (“key-signals” excito-amino acids, β-amyloid peptides and α-synuclein) are not only involved in information handling by the neuronal circuits, but also trig...
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Article
Implications of the ‘Energide’ concept for communication and information handling in the central nervous system
Recently a revision of the cell theory has been proposed, which has several implications both for physiology and pathology. This revision is founded on adapting the old Julius von Sach’s proposal (1892) of the En...
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Article
On the key role played by altered protein conformation in Parkinson’s disease
On the basis of the previously proposed hierarchic organisation of the central nervous system (CNS) and of its syntropic behaviour, a view of neurodegenerative diseases focusing on the assemblage of abnormal m...
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Article
Stimulation of D2 receptors in the prefrontal cortex reduces PCP-induced hyperactivity, acetylcholine release and dopamine metabolism in the nucleus accumbens
The aim of the present study was to investigate the effects of stimulation of D2 receptors in the prefrontal cortex (PFC) on spontaneous motor activity and the hyperactivity induced by the psychomimetic phency...
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Article
Nicotinic receptor agonists as neuroprotective/neurotrophic drugs. Progress in molecular mechanisms
In the present work we reviewed recent advances concerning neuroprotective/neurotrophic effects of acute or chronic nicotine exposure, and the signalling pathways mediating these effects, including mechanisms ...
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Article
Intramembrane receptor–receptor interactions: a novel principle in molecular medicine
In 1980/81 Agnati and Fuxe introduced the concept of intramembrane receptor–receptor interactions and presented the first experimental observations for their existence in crude membrane preparations. The secon...
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Article
Receptor–receptor interactions as studied with microdialysis. Focus on NTR/D2 interactions in the basal ganglia
Using mono and dualprobe(s) microdialysis in the basal ganglia of the freely moving rat evidence has been obtained that neurotensin (NT) in threshold concentrations can counteract the D2 agonist (intrastriatally ...
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Article
Receptor–receptor interactions in central cardiovascular regulation. Focus on neuropeptide/α2-adrenoreceptor interactions in the nucleus tractus solitarius
The nucleus tractus solitarii (NTS) is a key nucleus in central cardiovascular control. In this mechanism it is well known the role of the α2-adrenoreceptors for the modulation of the autonomic pathways. Moreover...
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Article
Receptor–receptor interactions involving adenosine A1 or dopamine D1 receptors and accessory proteins
The molecular basis for the known intramembrane receptor–receptor interactions among heptahelical receptors (G protein coupled receptors, GPCR) was postulated to be heteromerization based on receptor subtype s...
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Article
Aβ peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer’s disease
Amyloid peptides (Aβ) can operate as volume transmission (VT) signals since they are continuously released from cells of the central nervous system and diffuse in the extra-cellular space of the brain. They ha...
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Article
The brain as a system of nested but partially overlap** networks. Heuristic relevance of the model for brain physiology and pathology
A new model of the brain organization is proposed. The model is based on the assumption that a global molecular network enmeshes the entire central nervous system. Thus, brain extra-cellular and intra-cellular...
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Article
A boolean network modelling of receptor mosaics relevance of topology and cooperativity
In the last five years data have been obtained showing that a functional cross-talk among G Protein Coupled receptors (GPCR) exists at the plasma membrane level where they can dimerise and are able to generate...
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Article
Preface – Special Issue: Neural Communication, Neurotransmitters and Aging
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Studies on homocysteine plasma levels in Alzheimer’s patients. Relevance for neurodegeneration
Homocysteine (HC) may work inter alia as a Volume Transmission signal since HC is present in the brain and cerebrospinal fluid and binds to NMDA receptors. Furthermore, in cell cultures increased HC formation ...
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Article
Dynamics of volume transmission in the brain. Focus on catecholamine and opioid peptide communication and the role of uncoupling protein 2
This review focuses on transmitter-receptor mismatches in the brain, which is one of the hallmarks of the Volume Transmission (VT) concept, and how this phenomenon may be related to local temperature gradients...
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Article
Energy gradients for the homeostatic control of brain ECF composition and for VT signal migration: introduction of the tide hypothesis
The present paper enlightens a new point of view on brain homeostasis and communication, namely how the brain takes advantage of different chemical-physical phenomena such as pressure waves, and temperature an...
