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Article
Low serum inhibin B levels as a marker of testicular damage after treatment for a childhood malignancy
The aim of this study was to evaluate the role of inhibin B and the determination of its concentration to diagnose testicular damage after treatment for a childhood malignancy. Thirty-seven males treated for ...
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Article
Abnormal insulin response to glucose following treatment for Wilms' tumor in childhood
To determine whether β-cell function could be impaired by the treatment for Wilms' tumour (WT) in childhood, we investigated the insulin secretion of 44 survivors of WT (22 males) with a median off-treatment ...
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Article
Longitudinal growth and final height in long-term survivors of childhood leukaemia
Survival of children with acute lymphoblastic leukaemia (ALL) has increased considerably in recent years and data on the spontaneous growth and final height of these children are conflicting. Therefore, we ana...
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Article
HYPODIPSIA-HYPERNATREMIA SYNDROME - A PEDIATRIC CASE REPORT
The cases of chronic hypodipsis and hypernatremia represent a rarity, especially for the pediatric age group, and are mostly reported as “neurogenic” or “essential” hypernatremia. This paper describes a 2 3/12...
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Article
What will be the adult height of coeliac patients?
We studied three groups of patient with coeliac disease: group 1=95 adult patients with gastro-intestinal symptoms diagnosed after reaching adult height, 41 of whom had had symptoms during childhood; group 2=2...
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Article
Isolated dehydroepiandrosterone sulphate hypersecretion: A case report
The case of a 17-year-old male with isolated hypersecretion of dehydroepiandrosterone sulphate (DHEAS) is described. Cushing syndrome, congenital adrenal hyperplasia due to 3β-hydroxysteroid dehydrogenase defi...
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Article
116 GROWTH FACTORS IN HUMAN FOETAL PLASMA DURING THE SECOND TRIMESTER OF GESTATION: “IN UTERO” STUDY
The role of growth factors in fetal development is not clear. Fetal blood was obtained from 61 fetuses aged 19-25 weeks during the course of funicolocentesis performed for: suspected thalassaemia, fetal malfor...
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Article
83 VARIABILITY OF ARGININL-DOPA AND SLEEP TEST PERFORMED TWICE IN THE SAME PATIENTS
We performed arginine and sleep tests (blood samples from latter collected every 30′ for 12 hours) twice within two weeks in 21 short patients with mean C.A. 11.15 years (range 7.5 - 15.91 years); 14 males, 7 ...
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Article
69 HORMONAL, AUXOLOGICAL AND ANTHROPOMETRIC ASPECTS IN YOUNG FOOTBALL PLAYERS
Hormonal parameters (SmC, GH, Testosterone (T) and DHAS), lenght and width measures, body composition and biological maturation (bone age, pubic hair, testicular volume) indicators were used to evaluate during...
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Article
136 TREATMENT OF PRECOCIOUS PUBERTY BY INIRANASAL D-SER (TBU)6 LHRHI – 9EA10(BUSERELIN
GnRH analogues afford effective, selective, reversible inhibition of pituitary gonadotropin secretion. We administered Buserelin (300 ug × 6/die) to 18 girls affected by precocious puberty, for 6-24 months (on...
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Article
150 GONADAL HITOLOGY IN TWENTY SUBJECTS WITH MAL PSEUDO – HERNAFRODITISM
Gonadal histology was investigated by means of conventional microscopy in 11 Complete Adrogen insensitivity Syndrome (CAIS), in 5 Incomplete Adrogen Insensitivity Syndrome (IAIS) and in 4 5αreductase deficienc...
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Article
115 EFFECT OF GONADECTOMY ON GROWTH FACTORS IN TESTICULAR FENINIZED CHILDREN
Sm-C increase during puberty or sex hormones treatment. Whether this increase is mediated by GH is still unclear. Children with testicular feminization submitted to gonadectomy provide a good model to assess t...
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Article
82 RESPONSIVENESS OF PITUTARY hGH TO CRF IN JUNVENILES WITH SIMPLE OBESITY
It has been found that in obesity the response of plasma hGH to the pharmacological stimuli is blunted and the episodic output of hGH during sleep is also subnormal. The response of plasma hGH to an iv bolus o...
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Article
Differences in carbohydrate tolerance in Turner syndrome depending on age and karyotype
Carbohydrate homeostasis was evaluated in 47 girls with Turner syndrome and in 25 “short normal” girls by means of an oral glucose tolerance test. Of the Turner patients 34% showed an impaired glucose toleranc...
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Article
Haemorheologic and fibrinolytic evaluation in obese children and adolescents
The haemorheologic condition was evaluated in 43 obese children and 35 controls. In 18 of the obese children and in 21 controls the euglobulin lysis time (ELT) was also studied. Blood viscosity at 94.5 and at ...
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Article
Breast contact thermography for differentiation between premature thelarche and true precocious puberty
Breast contact thermography was used to differentiate between premature thelarche and true precocious puberty. The technique was applied to 10 girls with premature thelarche, 12 with precocious puberty and 105...
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Article
TREATMENT WITH CLONIDINE IN SUBJECTS WITH CONSTITUTIONAL GROWTH DELAY (CGO): A CONTROLLED DOUBLE-BLIND STUDY
In 1985, Pintor et al. reported that treatment with clonidine (CI), an α2-a-drenergic agonist, accelerates growth in children with growth disorders. In order to confirm or disprove this observation, we studied...
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Article
WILMS' TUMOUR: AUXOLOGICAL AND ENDOCRINOLOGICAL STUDY
In Wilm's tumour, there is frequent spontaneous deletion of chromosome 11 and insulin and growth factor genes are located close to the deletion area. We studied growth and glycemia situation in 42 Wilms tumour...
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Article
GROWTH AND PITUITARY FUNCTION IN CHILDREN TREATED FOR ACUTE LYMPHATIC LEUKEMIA (ALL)
52 children in continuous complete remission from ALL and off all drugs for 2 years were studied. 39 had received cranial irradiation with 2400 cGy (group I) and 13 with 1800 cGy (group II). Height was measure...
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Article
EFFECT OF ESTROGEN-PROGESTOGEN TREATMENT ON CARBOHYDRATE TOLERANCE IN TURNER'S SYNDROME
Glucose tolerance was evaluated by means of an OGTT in 16 girls with Turner's syndrome submitted to estrogen-progestogen treatment (10 subjects 45, X, 1 X-mosaic and 5 X structural abnormalities). OGTT was per...