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Article
Effect of Sulphadiazine on the Metabolism of Aneurin in Animals
IT is well established that some of the toxic effects of sulphonamides on animals fed purified diets are caused by inhibition of bacterial synthesis of some B vitamins in the intestine, with consequent develop...
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Article
A Factor in Heart Muscle Required for the Reduction of Cytochrome c by Cytochrome b
IT is well established1 that the intracellular respiratory complex catalysing the aerobic oxidation of succinate (the succinic oxidase system) includes the cytochrome system in addition to the specific enzyme ...
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Article
'Cytochrome c1' of Yakushiji and Okuniki
Yakushiji and Okuniki1 claimed to have demonstrated the existence of a new component (cytochrome c1 of the succinic oxidase system, acting between cytochromes b and c, that is, with the same function as the respi...
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Article
Stabilization of Oxidative Phosphorylation in Heart-Muscle Sarcosomes
FRESHLY prepared suspensions of the granular components of heart-muscle (sarcosomes1, interstitial granules2 or mitochondria3) are able to oxidize a number of intermediary metabolites, and to couple this oxidatio...
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Book and Conference Proceedings
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Chapter and Conference Paper
Structurally-bound enzymes
It is likely that, within the intact cell, the freedom of movement of all enzymes is restricted. To that extent they could all be considered structurally-bound. However, from the purely experimental point of v...
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Article
Phosphorylation coupled with the Oxidation of Ferrocytochrome c by Heart Sarcosomes
Nielsen and Lehninger1 have recently demonstrated the incorporation of phosphorus-32 into organic phosphate during the aerobic oxidation of ferrocytochrome c by rat-liver mitochondria in the presence of adenosine...
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Article
Respiratory Chain Phosphorylation in Extracts of Azotobacter vinelandii
RESPIRATORY chain phosphorylation has been demonstrated in crude extracts of a few bacterial species1–4, and in one case the extract was separated into three components which were all necessary for phosphorylatio...
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Article
Tocopherol Content of Heart-muscle Preparations
THE possible role of vitamin E in respiratory enzyme systems has often been suggested; but supporting evidence of the actual presence of vitamin E in active enzyme preparations has not been published. We have ...
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Article
Enzymes
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Article
Need for Inorganic Phosphate in Oxidations stimulated by Dinitrophenol
IN an experiment with a phosphorylating kidney -cyclophorase preparation Loomis and Lipmann1 discovered that 2,4-dinitrophenol could replace the inorganic phosphate necessary for a maximal rate of oxygen uptake w...
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Chapter
Der Chemismus der biologischen Oxydationen und Oxydoreduktionen
Unsere Vorstellungen über die Atmungskette, die den Haupt weg des Transportes von Elektronen oder Wasserstoff von den Stoffwechselsubstanzen zum Sauerstoff darstellt, sind als ein Ergebnis der Forschungen der ...
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Article
Need for Inorganic Phosphate in Oxidations stimulated by Dinitrophenol
Recently we have reported, in disagreement with the widely accepted view, that the maximal rate of oxygen uptake by respiring rat-liver or rat-heart mitochondria with glutamate as substrate is not obtained wit...
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Article
Effect of Heavy Water on Respiratory-chain Enzymes
DURING radiobiological work on bacteria it was found by one of us (H. L.) that the effect of ionizing radiation (X-rays) is greatly potentiated if the bacteria are irradiated in a medium in which water is repl...
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Book
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Article
Oxidases and Related Oxidation-Reduction Systems
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Article
Labelling Rates and Detection of Intermediates in Mitochondrial Phosphorylations and other Sequential Reactions
BASED on his observation that mitochondrial protein-bound phosphohistidine becomes maximally labelled with added radioactive inorganic phosphate before maximum labelling of the mitochondrial ATP is reached, Pr...
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Chapter
An Evaluation of the Mitchell Hypothesis of Chemiosmotic Coupling in Oxidative and Photosynthetic Phosphorylation
The Mitchell hypothesis of chemiosmotic coupling in oxidative phosphorylation is examined in the light of experimental data on oxidative phosphorylation at present available. The following objections are broug...
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Chapter and Conference Paper
Applications of Oligomycin and Related Inhibitors in Bioenergetics
Oligomycin is a fungicide made by Streptomyces diastatochromo- genes and related strains [1].
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Chapter and Conference Paper
Inhibitors Around the Antimycin-Sensitive Site in the Respiratory Chain
The region of the respiratory chain between cytochromes b and c1 is affected by several compounds in such a way as to lead to inhibition of electron transport. The site of action of these inhibitors is usually ca...
