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Article
Open AccessDistinct spatial immune microlandscapes are independently associated with outcomes in triple-negative breast cancer
The utility of spatial immunobiomarker quantitation in prognostication and therapeutic prediction is actively being investigated in triple-negative breast cancer (TNBC). Here, with high-plex quantitative digit...
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Article
Open AccessRejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance
Cellular senescence is a plausible mediator of inflammation-related tissue dysfunction. In the aged brain, senescent cell identities and the mechanisms by which they exert adverse influence are unclear. Here w...
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Article
Open AccessEvidence of cerebellar TDP-43 loss of function in FTLD-TDP
Frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) is a neurodegenerative disease primarily affecting the frontal and/or temporal cortices. However, a growing body of evidence suggests that the...
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Article
Open AccessTowards defining morphologic parameters of normal parous and nulliparous breast tissues by artificial intelligence
Breast terminal duct lobular units (TDLUs), the source of most breast cancer (BC) precursors, are shaped by age-related involution, a gradual process, and postpartum involution (PPI), a dramatic inflammatory p...
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Article
Open AccessAdaptive immune signature in HER2-positive breast cancer in NCCTG (Alliance) N9831 and NeoALTTO trials
Trastuzumab acts in part through the adaptive immune system. Previous studies showed that enrichment of immune-related gene expression was associated with improved outcomes in HER2-positive (HER2+) breast canc...
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Article
Open AccessElevated methylation levels, reduced expression levels, and frequent contractions in a clinical cohort of C9orf72 expansion carriers
A repeat expansion in the C9orf72-SMCR8 complex subunit (C9orf72) is the most common genetic cause of two debilitating neurodegenerative diseases: amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (...
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Article
Open AccessChromoanasynthesis is a common mechanism that leads to ERBB2 amplifications in a cohort of early stage HER2+ breast cancer samples
HER2 positive (HER2+) breast cancers involve chromosomal structural alterations that act as oncogenic driver events.
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Article
Open AccessNanoString-based breast cancer risk prediction for women with sclerosing adenosis
Sclerosing adenosis (SA), found in ¼ of benign breast disease (BBD) biopsies, is a histological feature characterized by lobulocentric proliferation of acini and stromal fibrosis and confers a two-fold increas...
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Article
Open AccessCorrection: Corrigendum: Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth
Scientific Reports 6: Article number: 25521; published online: 10 May 2016; updated: 30 June 2017 This Article contains errors in the frequencies of ESR1 amplifications concerning uterine corpus endometrioid c...
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Article
Open AccessThe antineoplastic drug, trastuzumab, dysregulates metabolism in iPSC-derived cardiomyocytes
The targeted ERBB2 therapy, trastuzumab, has had a tremendous impact on management of patients with HER2+ breast cancer, leading to development and increased use of further HER2 targeted therapies. The major c...
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Article
Open AccessCorrection: Corrigendum: Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth
Scientific Reports 6: Article number: 25521; published online: 10 May 2016; updated: 24 June 2016 In the original version of this Article, there were errors in Affiliation 2 which was incorrectly given as ‘KG ...
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Open AccessRecurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth
The estrogen receptor alpha (ERα) is highly expressed in both endometrial and breast cancers, and represents the most prevalent therapeutic target in breast cancer. However, anti-estrogen therapy has not been ...
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Article
Open AccessThe relationship between quantitative human epidermal growth factor receptor 2 gene expression by the 21-gene reverse transcriptase polymerase chain reaction assay and adjuvant trastuzumab benefit in Alliance N9831
The N9831 trial demonstrated the efficacy of adjuvant trastuzumab for patients with human epidermal growth factor receptor 2 (HER2) locally positive tumors by protein or gene analysis. We used the 21-gene assa...
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Article
Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity
E-cadherin and p120 catenin (p120) are essential for epithelial homeostasis, but can also exert pro-tumorigenic activities. Here, we resolve this apparent paradox by identifying two spatially and functionally ...
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Article
Open AccessPharmacologic reversion of epigenetic silencing of the PRKD1promoter blocks breast tumor cell invasion and metastasis
DNA methylation-induced silencing of genes encoding tumor suppressors is common in many types of cancer, but little is known about how such epigenetic silencing can contribute to tumor metastasis. The PRKD1 gene ...
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Article
Open AccessPotential for the embryonic morphogen Nodal as a prognostic and predictive biomarker in breast cancer
The re-emergence of the tumour growth factor-beta (TGF-beta)-related embryonic morphogen Nodal has recently been reported in several different human cancers. In this study, we examined the expression of Nodal ...
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Protocol
Gene Expression Profiling Using 3′ Tag Digital Approach
Massive parallel sequencing will become the method of choice for transcriptome profiling. Two protocols have been developed to quantify level of expressions: full-length RNA sequencing (RNA-SEQ) and 3′ tag dig...
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Article
Adjuvant therapy of triple negative breast cancer
Patients with the triple negative subtype of breast cancer have an overall poor outcome, with earlier relapses, distinct patterns of metastases, and lack of specific targets for treatment selection. Classifica...
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Article
Open Access3' tag digital gene expression profiling of human brain and universal reference RNA using Illumina Genome Analyzer
Massive parallel sequencing has the potential to replace microarrays as the method for transcriptome profiling. Currently there are two protocols: full-length RNA sequencing (RNA-SEQ) and 3'-tag digital gene e...
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Article
Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β-induced apoptosis
Transforming growth factor β (TGF-β) induces both apoptosis and cell-cycle arrest in some cell lines, but only growth arrest in others1. It is not clear how this differential response to TGF-β is specified. Smad ...
