5 Result(s)
within
Donghoon Lee
Life Sciences
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Article
Open AccessSTARRPeaker: uniform processing and accurate identification of STARR-seq active regions
STARR-seq technology has employed progressively more complex genomic libraries and increased sequencing depths. An issue with the increased complexity and depth is that the coverage in STARR-seq experiments is...
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Article
Open AccessNIMBus: a negative binomial regression based Integrative Method for mutation Burden Analysis
Identifying frequently mutated regions is a key approach to discover DNA elements influencing cancer progression. However, it is challenging to identify these burdened regions due to mutation rate heterogeneit...
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Article
Open AccessRADAR: annotation and prioritization of variants in the post-transcriptional regulome of RNA-binding proteins
RNA-binding proteins (RBPs) play key roles in post-transcriptional regulation and disease. Their binding sites cover more of the genome than coding exons; nevertheless, most noncoding variant prioritization me...
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Article
Open AccessDiNeR: a Differential graphical model for analysis of co-regulation Network Rewiring
During transcription, numerous transcription factors (TFs) bind to targets in a highly coordinated manner to control the gene expression. Alterations in groups of TF-binding profiles (i.e. “co-binding changes”...
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Article
MicroRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis
Vertebrate tissues exhibit mechanical homeostasis, showing stable stiffness and tension over time and recovery after changes in mechanical stress. However, the regulatory pathways that mediate these effects ar...
