30 Result(s)
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Article
Open AccessTargeting CXCR4/CXCL12 axis via [177Lu]Lu-DOTAGA.(SA.FAPi)2 with CXCR4 antagonist in triple-negative breast cancer
Radiopharmaceutical therapies targeting fibroblast activation protein (FAP) have shown promising efficacy against many tumor types. But radiopharmaceuticals alone in most cases are insufficient to completely e...
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Open AccessCorrelation of meniscus tear type with synovial inflammation and the therapeutic potential of docosapentaenoic acid
Synovitis, characterized by inflammation of the synovial membrane, is commonly induced by meniscus tears. However, significant differences in inflammatory responses and the key inflammatory mediators of synovi...
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Association of preoperative aneurysmal wall enhancement with relief of chronic headache after surgical clip** of unruptured intracranial aneurysms
To investigate the association between chronic headache outcome and aneurysmal wall enhancement (AWE) on high-resolution vessel wall imaging (HR-VWI) in patients with unruptured intracranial aneurysms (UIAs) w...
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Mitochondrial myopathy without extraocular muscle involvement: a unique clinicopathologic profile
Mitochondrial myopathy without extraocular muscles involvement (MiMy) represents a distinct form of mitochondrial disorder predominantly affecting proximal/distal or axial muscles, with its phenotypic, genotyp...
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Glioblastomas with and without peritumoral fluid-attenuated inversion recovery (FLAIR) hyperintensity present morphological and microstructural differences on conventional MR images
Glioblastoma (GB) without peritumoral fluid-attenuated inversion recovery (FLAIR) hyperintensity is atypical and its characteristics are barely known. The aim of this study was to explore the differences in pa...
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Predicting peritumoral edema development after gamma knife radiosurgery of meningiomas using machine learning methods: a multicenter study
Edema is a complication of gamma knife radiosurgery (GKS) in meningioma patients that leads to a variety of consequences. The aim of this study is to construct radiomics-based machine learning models to predic...
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Open AccessAnti-PD-1 antibody armored γδ T cells enhance anti-tumor efficacy in ovarian cancer
γδ T cells have the unique ability to detect a wide range of tumors with low mutation burdens, making them attractive candidates for CAR-T-cell therapy. Unlike αβ T cells and other immune cells, γδ T cells are...
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Open AccessHSDL2 knockdown promotes the progression of cholangiocarcinoma by inhibiting ferroptosis through the P53/SLC7A11 axis
Human hydroxysteroid dehydrogenase-like 2 (HSDL2), which regulates cancer progression, is involved in lipid metabolism. However, the role of HSDL2 in cholangiocarcinoma (CCA) and the mechanism by which it regu...
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Open AccessApplication of mesohepatectomy with caudate lobectomy for the treatment of type III–IV hilar cholangiocarcinoma: a single-center retrospective study
The main surgical procedure for Bismuth‒Corlette III–IV hilar cholangiocarcinoma (HCCA) is hemihepatectomy/extended hemihepatectomy. However, many patients have no opportunity for surgery due to having an insu...
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Open AccessAcute traumatic coma awakening by right median nerve electrical stimulation: a randomised controlled trial
Severe traumatic brain injury (TBI) leads to acute coma and may result in prolonged disorder of consciousness (pDOC). We aimed to determine whether right median nerve electrical stimulation is a safe and effec...
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Open AccessCorrelation between osteoprotegerin and coronary artery calcification in diabetic subjects: a systematic review of observational studies
Coronary artery calcification (CAC) is one of the critical cardiovascular complications that lead to elevated morbidity and mortality among patients with type 2 diabetes (T2M). The association between osteopro...
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Open AccessRisk assessment of cytologically indeterminate thyroid nodules with integrated molecular testing and repeat biopsy: a surgical decision-oriented tool
The preoperative diagnosis of cytologically indeterminate thyroid nodules (ITNs) is very challenging. In this study, we aim to provide an integrated risk assessment for thyroid nodules with indeterminate cytol...
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Based on the IWATE criteria: to investigate the influence of different surgical approaches on the perioperative outcomes of hepatectomy
In terms of perioperative outcomes, compared with traditional open surgery and laparoscopic surgery, studies of robotic liver resection have been limited and must be further clarified.
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Open AccessInfluencing factors of biliary fistula after radical resection of hilar cholangiocarcinoma: a prospect cohort
Biliary fistula is a common but serious complication after radical resection of hilar cholangiocarcinoma. We aimed to evaluate the influencing factors of biliary fistula after radical resection, to provide ins...
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Article
Assessment of dynamic hepatic and renal imaging changes in COVID-19 survivors using T1 map** and IVIM-DWI
To explore the imaging changes of the liver and kidneys in COVID-19 survivors using variable flip angle (VFA) T1 map** and intravoxel incoherent motion-diffusion weighted imaging (IVIM-DWI).
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Open AccessPerformances of clinical characteristics and radiological findings in identifying COVID-19 from suspected cases
To identify effective factors and establish a model to distinguish COVID-19 patients from suspected cases.
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Open AccessDifferentiating nontuberculous mycobacterium pulmonary disease from pulmonary tuberculosis through the analysis of the cavity features in CT images using radiomics
To differentiate nontuberculous mycobacteria (NTM) pulmonary diseases from pulmonary tuberculosis (PTB) by analyzing the CT radiomics features of their cavity.
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Article
GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease
Growth differentiation factor 15 (GDF15) is a member of the TGFβ superfamily whose expression is increased in response to cellular stress and disease as well as by metformin. Elevations in GDF15 reduce food in...
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Open AccessProgrammed cell death 4 as an endogenous suppressor of BDNF translation is involved in stress-induced depression
Brain-derived neurotrophic factor (BDNF) is a growth factor that plays vital roles in the neuron survival, growth, and neuroplasticity. Alteration to BDNF expression is associated with major depressive disorde...
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Open AccessA diet high in sugar and fat influences neurotransmitter metabolism and then affects brain function by altering the gut microbiota
Gut microbiota (GM) metabolites can modulate the physiology of the host brain through the gut–brain axis. We wished to discover connections between the GM, neurotransmitters, and brain function using direct an...
