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  1. No Access

    Chapter

    The Neural Crest

    The concept of the epithelial-mesenchymal transition (EMT) arose from developmental biology, (see ref. 1) where EMT occurs in many situations, each being predictable, stereotyped and with the outcomes often dr...

    Donald F. Newgreen, Sonja J. McKeown in Rise and Fall of Epithelial Phenotype (2005)

  2. No Access

    Chapter

    Matrix Metalloproteases and Epithelial-to-Mesenchymal Transition

    The epithelial to mesenchymal transition (EMT) is characterized by the loss of epithelial characteristics and the gain of mesenchymal attributes in epithelial cells. It has been associated with physiological a...

    Christine Gilles, Donald F. Newgreen, Hiroshi Sato… in Rise and Fall of Epithelial Phenotype (2005)

  3. Article

    Open Access

    Induction of epithelial to mesenchymal transition in PMC42-LA human breast carcinoma cells by carcinoma-associated fibroblast secreted factors

    Breast carcinoma is accompanied by changes in the acellular and cellular components of the microenvironment, the latter typified by a switch from fibroblasts to myofibroblasts.

    Stephanie C Lebret, Donald F Newgreen, Erik W Thompson… in Breast Cancer Research (2007)

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  4. Article

    Open Access

    Staurosporine augments EGF-mediated EMT in PMC42-LA cells through actin depolymerisation, focal contact size reduction and Snail1 induction – A model for cross-modulation

    A feature of epithelial to mesenchymal transition (EMT) relevant to tumour dissemination is the reorganization of actin cytoskeleton/focal contacts, influencing cellular ECM adherence and motility. This is cou...

    Honor J Hugo, Razan Wafai, Tony Blick, Erik W Thompson, Donald F Newgreen in BMC Cancer (2009)

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  5. No Access

    Article

    Contribution of Fibroblast and Mast Cell (Afferent) and Tumor (Efferent) IL-6 Effects within the Tumor Microenvironment

    Hyperactive inflammatory responses following cancer initiation have led to cancer being described as a ‘wound that never heals’. These inflammatory responses elicit signals via NFκB leading to IL-6 production,...

    Honor J. Hugo, Stephanie Lebret, Eva Tomaskovic-Crook… in Cancer Microenvironment (2012)

  6. Article

    Open Access

    Direct repression of MYB by ZEB1 suppresses proliferation and epithelial gene expression during epithelial-to-mesenchymal transition of breast cancer cells

    Epithelial-to-mesenchymal transition (EMT) promotes cell migration and is important in metastasis. Cellular proliferation is often downregulated during EMT, and the reverse transition (MET) in metastases appea...

    Honor J Hugo, Lloyd Pereira, Randy Suryadinata, Yvette Drabsch… in Breast Cancer Research (2013)

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  7. Article

    Open Access

    Guidelines and definitions for research on epithelial–mesenchymal transition

    Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occ...

    **g Yang, Parker Antin, Geert Berx… in Nature Reviews Molecular Cell Biology (2020)

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  8. Article

    Open Access

    Author Correction: Guidelines and definitions for research on epithelial–mesenchymal transition

    **g Yang, Parker Antin, Geert Berx… in Nature Reviews Molecular Cell Biology (2021)

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