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Article
Open AccessA resonant high-pressure microsensor based on a composite pressure-sensitive mechanism of diaphragm bending and volume compression
In this paper, a composite pressure-sensitive mechanism combining diaphragm bending and volume compression was developed for resonant pressure microsensors to achieve high-pressure measurements with excellent ...
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Article
Open AccessA novel evolutionary method for parameter-free MEMS structural design and its application in piezoresistive pressure sensors
In this paper, a novel simulation-based evolutionary method is presented for designing parameter-free MEMS structures with maximum degrees of freedom. This novel design method enabled semiautomatic structure e...
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Interpretation of preliminary electrical data in impedance flow cytometry: numerical simulation, theoretical analysis, and neural net fitting
As a label-free tool, single-cell impedance flow cytometry is an effective method to measure electrical properties and distinguish cell populations. However, interpretation of preliminary electrical data in im...
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Article
Open AccessA micromachined electrochemical angular accelerometer with highly integrated sensitive microelectrodes
This paper presents a micromachined electrochemical angular accelerometer with highly integrated sensitive microelectrodes. Theoretical analyses and numerical simulations were conducted to model the angular ac...
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Article
Open AccessA new electrochemical angular microaccelerometer with integrated sensitive electrodes perpendicular to flow channels
A new electrochemical angular microaccelerometer with integrated sensitive electrodes perpendicular to flow channels was developed in this paper. Based on a liquid inertial mass, an incoming angular accelerati...
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Reference Work Entry In depth
Single-Cell Impedance Flow Cytometry
This chapter reviews recent technical developments in the field of single-cell electrical property characterization. Firstly, three well-established characterization approaches including patch clam**, electr...
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Article
A droplet-based microfluidic flow cytometry enabling absolute quantification of single-cell proteins leveraging constriction channel
Measurements of single-cell proteins provide key insights in studies related to cellular heterogeneities, while the absolute quantification of single-cell non-surface proteins remains elusive. This paper prese...
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Development of microfluidic platform capable of characterizing cytoplasmic viscosity, cytoplasmic conductivity and specific membrane capacitance of single cells
This paper presents a microfluidic platform capable of characterizing cytoplasmic viscosity μcy, cytoplasmic conductivity σcy and specific membrane capacitance Csm of single cells continuously. A travelling cell ...
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Article
Optimization of LC sensor enabling wireless passive intracranial pressure monitoring
With the increasingly widespread researches of wireless passive sensing technology based on LC sensors in the field of intracranial pressure (ICP) monitoring and other biomedical applications, the importance o...
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Living Reference Work Entry In depth
Single-Cell Impedance Flow Cytometry
This chapter reviews recent technical developments in the field of single-cell electrical property characterization. Firstly, three well-established characterization approaches including patch clam**, electr...
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Article
Open AccessA Microfluidic Fluorescent Flow Cytometry Capable of Quantifying Cell Sizes and Numbers of Specific Cytosolic Proteins
This study presents a microfluidics based cytometry capable of characterizing cell sizes and counting numbers of specific cytosolic proteins where cells were first bound by antibodies labelled with fluorescenc...
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Reference Work Entry In depth
A Micromachined Silicon Resonant Pressure Sensor
Micromachined silicon resonant pressure sensors have been widely used in automotive industry, medical instrument, aerospace, and military fields due to their high accuracy, long-term stability, and quasi-digit...
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Article
Open AccessA Microfabricated 96-Well 3D Assay Enabling High-Throughput Quantification of Cellular Invasion Capabilities
This paper presents a 96-well microfabricated assay to study three-dimensional (3D) invasion of tumor cells. A 3D cluster of tumor cells was first generated within each well by seeding cells onto a micro-patte...
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Article
Open AccessSpecific membrane capacitance, cytoplasm conductivity and instantaneous Young’s modulus of single tumour cells
As label-free biomarkers, biophysical properties of cells are widely used for cell type classification. However, intrinsic biophysical markers, e.g., specific membrane capacitance (Cspecific membrane), cytoplasm ...
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Living Reference Work Entry In depth
A Micromachined Silicon Resonant Pressure Sensor
Micromachined silicon resonant pressure sensors have been widely used in automotive industry, medical instrument, aerospace, and military fields due to their high accuracy, long-term stability, and quasi-digit...
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Article
Open AccessSingle-Cell Electrical Phenoty** Enabling the Classification of Mouse Tumor Samples
Single-cell electrical phenoty** (e.g., specific membrane capacitance (Cm) and cytoplasm conductivity (σp)) has long been regarded as potential label-free biophysical markers in tumor status evaluation. However...
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Chapter
Single-Cell Mechanical Properties: Label-Free Biomarkers for Cell Status Evaluation
The mechanical behavior of biological cells is largely determined by their cytoskeletons; abnormal cellular functions can change cytoskeletons, leading to variations in cellular mechanical properties. This cha...
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Article
Open AccessA Tubing-Free Microfluidic Wound Healing Assay Enabling the Quantification of Vascular Smooth Muscle Cell Migration
This paper presents a tubing-free microfluidic wound healing assay to quantify the migration of vascular smooth muscle cells (VSMCs), where gravity was used to generate a laminar flow within microfluidic chann...
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In Vitro and In Vivo characterization of wireless and passive micro system enabling gastrointestinal pressure monitoring
This paper presents a wireless and passive micro pressure system based on the LC mutual inductance detection mechanism for gastrointestinal (GI) pressure monitoring. The micro pressure system is composed of a ...
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Fabrication and test of an electromagnetic vibrating ring gyroscope based on SOI wafer
Mode matching is the key to improve the performance of micro-machined vibrating ring gyroscopes. Mass and stiffness asymmetries can lend to normal modes badly mismatch for gyroscopes fabricated by single-cryst...
