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Article
START smuggling CoQ to fight ferroptosis
Extramitochondrial coenzyme Q (CoQ) can function as a potent anti-ferroptosis radical trapper. However, it is largely unknown how CoQ is transported from mitochondria to the plasma membrane. A study now sugges...
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Article
A new checkpoint against ferroptosis
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Article
Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis
The antimalarial drug artemisinin and its derivatives have been explored as potential anticancer agents, but their underlying mechanisms are controversial. In this study, we found that artemisinin compounds ca...
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Article
Erratum: Lineage specification of human dendritic cells is marked by IRF8 expression in hematopoietic stem cells and multipotent progenitors
Nat. Immunol.; doi:10.1038/ni.3789; corrected online 5 July 2017 In the version of this article initially published online, the flow cytometric dots were missing in the middle plot of the leftmost column in Fi...
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Article
Lineage specification of human dendritic cells is marked by IRF8 expression in hematopoietic stem cells and multipotent progenitors
Liu and colleagues show that specification of the dendritic-cell lineage occurs in parallel with specification of the myeloid and lymphoid lineages in or around the hematopoietic-stem-cell stage, starting as a...
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Article
A human herpesvirus miRNA attenuates interferon signaling and contributes to maintenance of viral latency by targeting IKKɛ
Type I interferon (IFN) signaling is the principal response mediating antiviral innate immunity. IFN transcription is dependent upon the activation of transcription factors IRF3/IRF7 and NF-κB. Many viral prot...
