19 Result(s)
within
David M. Jablons
English
Oncology
-
Chapter
Lung Cancer Staging and Prognosis
The seventh edition of the non-small cell lung cancer (NSCLC) TNM staging system was developed by the International Association for the Staging of Lung Cancer (IASLC) Lung Cancer Staging Project by a coordinat...
-
Article
Measurement of genome-wide DNA methylation predicts survival benefits from chemotherapy in non-small cell lung cancer
Novel molecular predictive biomarkers for chemotherapy have been screened and validated in non-small cell lung cancer (NSCLC). However, there was no report on the correlation of genome-wide DNA methylation wit...
-
Chapter
Lung Cancer Stem Cells
Lung cancer remains the leading cause of cancer mortality and novel therapies are desperately needed to treat metastatic and recurrent disease. The cancer stem cell hypothesis is based on data that within each...
-
Article
Open AccessCK2α, over-expressed in human malignant pleural mesothelioma, regulates the Hedgehog signaling pathway in mesothelioma cells
The Hedgehog (Hh) signaling pathway has been implicated in stem cell maintenance and its activation is aberrant in several types of cancer including mesothelioma. Protein kinase CK2 affects several cell signal...
-
Article
Open AccessHedgehog/Gli promotes epithelial-mesenchymal transition in lung squamous cell carcinomas
Squamous cell carcinomas (SCC) account for approximately 30% of non-small cell lung cancer. Investigation of the mechanism of invasion and metastasis of lung SCC will be of great help for the development of me...
-
Article
Open AccessFrizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer
Wnt-2 plays an oncogenic role in cancer, but which Frizzled receptor(s) mediates the Wnt-2 signaling pathway in lung cancer remains unclear. We sought to (1) identify and evaluate the activation of Wnt-2 signa...
-
Article
Open AccessDetection of E2A-PBX1 fusion transcripts in human non-small-cell lung cancer
E2A-PBX1 fusion gene caused by t(1;19)(q23;p13), has been well characterized in acute lymphoid leukemia (ALL). There is no report on E2A-PBX1 fusion transcripts in non-small-cell lung cancer (NSCLC).
-
Article
Open AccessSMO expression level correlates with overall survival in patients with malignant pleural mesothelioma
Malignant mesothelioma is an aggressive, treatment-resistant tumor arising from mesothelium of pleura, peritoneum and pericardium. Despite current combined regimen, its prognosis remains dismal, calling for mo...
-
Chapter
Hallmarks of Metastasis
Metastasis is rarely due to accidental sloughing off of cancerous cells from a nonmalignant tumor and colonizing elsewhere; on the contrary, it is an active process requiring genetic and/or epigenetic mechanis...
-
Article
Open AccessIdentification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library
Casein kinase 2 (CK2) is dysregulated in various human cancers and is a promising target for cancer therapy. To date, there is no small molecular CK2 inhibitor in clinical trial yet. With the aim to identify n...
-
Chapter
Stem Cells and Lung Cancer
Lung cancer with its more than 1 million deaths per year is the leading cause of cancer mortality for both men and women worldwide. Despite recent advances in current treatment modalities, overall survival rat...
-
Article
The role of cancer stem cells in neoplasia of the lung: past, present and future
Through the identification and subsequent targeting of an exquisitely unique and phenotypically defined cancer stem-cell population exhibiting discrete therapeutic vulnerabilities (a potential source of tumor ...
-
Article
Clinical patterns of metastasis
In human solid cancer, lymph node status is the most important indicator for clinical outcome. Recent developments in the sentinel lymph node concept and technology have resulted in a more precise way of exami...
-
Article
Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis
The Wnt family of secreted glycoproteins is widely involved in cell proliferation, differentiation and oncogenesis. Many Wnt signaling genes are upregulated and activated in chronic lymphocytic leukemia. Less ...
-
Article
Open AccessEfficacy of Wnt-1 monoclonal antibody in sarcoma cells
Sarcomas are one of the most refractory diseases among malignant tumors. More effective therapies based on an increased understanding of the molecular biology of sarcomas are needed as current forms of therapy...
-
Article
Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations
Aberrant Wnt signaling, mainly through mutations of APC and in some cases of CTNNB1 or AXIN2, has been found in the majority of colorectal cancers. Recently, frequent promoter hypermethylation was identified to c...
-
Article
Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma
Secreted frizzled-related proteins (sFRPs) comprise a family of five secreted glycoproteins that antagonize Wnt signaling. Aberrant activation and upregulation of the Wnt pathway is a key feature of many cance...
-
Article
Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells
In this report, we have demonstrated that Wnt-2 protein is overexpressed in freshly resected human non-small-cell lung cancer (NSCLC) tissues. We have also developed a monoclonal antibody against the N-terminu...
-
Protocol
Matrix Metalloproteinase Expression in Lung Cancer
The importance of matrix metalloproteinases (MMPs) in the growth and spread of solid tumors has been known for over a decade (1,2). However, the molecular mechanisms that regulate their expression and the elucida...
