From Local Invasion to Metastatic Cancer
Involvement of Distant Sites Through the Lymphovascular System
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Stanley P. L. Leong
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Chapter
Anatomy and Physiology of Lymphatic Circulation: Application to Lymphatic Map**
The lymphatic system is a field of continuing interest in oncology, both because of its role in the immune system and because it constitutes a major route of dissemination of cancers. Studies of its anatomy co...
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Article
Is the non-sentinel lymph node compartment the next site for melanoma progression from the sentinel lymph node compartment in the regional nodal basin?
Melanoma patients with additional positive lymph nodes in the completion lymph node dissection (CLND) following a positive sentinel lymph node (SLN) biopsy would have a poorer prognosis than patients with no a...
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Article
Biomarkers of cancer metastasis through the lymphovascular system: future perspectives
Cancer progression from the primary site to the regional lymph nodes and beyond to the distant sites through the lymphovascular system is genetically determined. In general, sentinel lymph node in the regional...
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Article
Erratum to: Progression of cutaneous melanoma: implications for treatment
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Editorial
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Lymphatics, lymph nodes and the immune system: barriers and gateways for cancer spread
Metastasis to the regional lymph node is the most important prognostic indicator for the outcomes of patients with sold cancer. In general, it is well recognized that cancer development is genetically determin...
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Progression of cutaneous melanoma: implications for treatment
The survival rates of melanoma, like any type of cancer, become worse with advancing stage. Spectrum theory is most consistent with the progression of melanoma from the primary site to the in-transit locations...
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Implementing Sentinel Lymph Node Biopsy Programs in Develo** Countries: Challenges and Opportunities
Sentinel lymph node biopsy (SLNB) is the accepted standard of care in early-stage breast cancer and cutaneous melanoma. This technology is accurate for nodal staging and determining the prognosis of these pati...
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Article
Open AccessIs Breast Cancer the Same Disease in Asian and Western Countries?
A mini-symposium was held in Montreal, Canada, at the International Surgical Week for the Breast Surgical International in 2007 addressing the question whether breast cancer is the same disease in Asian and We...
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Book
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Chapter
Future Perspectives for Cancer Metastasis: Unanswered Questions and Unquestioned Answers
In this sentinel lymph node (SLN) era, two new paradigms of cancer metastasis have emerged. First, in general, cancer spreads in a progressive fashion from the primary site to the SLNs and beyond to distant si...
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Reference Work Entry In depth
Surgical Treatment of Malignant Melanoma
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Article
Tumour-induced immune modulation of sentinel lymph nodes
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Tumour–induced immune modulation of sentinel lymph nodes
In most patients with melanoma who develop metastases, the regional lymph nodes are the first organs to be affected.
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Introduction
The first international symposium on Cancer Metastasis and Lymphovascular System: Basis for Rational Therapy was held in San Francisco from April 20–30, 2005. There were a total of seven sessions and three lun...
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Future perspectives for cancer metastasis and the lymphovascular system
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Clinical patterns of metastasis
In human solid cancer, lymph node status is the most important indicator for clinical outcome. Recent developments in the sentinel lymph node concept and technology have resulted in a more precise way of exami...
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Chapter
Future Perspectives
Cancers arise from their normal cellular counterparts, and, in this regard, malignant melanoma is no exception. Within this book, we have traced the origins of melanoblast precursors, their differentiation to ...
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Chapter
Paradigm of Metastasis for Malignant Melanoma
Melanomas usually progress from an in situ growth to a radial growth phase in which they expand into a vertical growth phase that is associated with an increased risk of metastasis. In general, the process metast...
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