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  1. No Access

    Article

    ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration

    Cardiomyocyte loss after injury results in adverse remodelling and fibrosis, inevitably leading to heart failure. The ERBB2–Neuregulin and Hippo–YAP signalling pathways are key mediators of heart regeneration,...

    Alla Aharonov, Avraham Shakked, Kfir Baruch Umansky, Alon Savidor… in Nature Cell Biology (2020)

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    Article

    ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation

    The murine neonatal heart can regenerate after injury through cardiomyocyte (CM) proliferation, although this capacity markedly diminishes after the first week of life. Neuregulin-1 (NRG1) administration has b...

    Gabriele D’Uva, Alla Aharonov, Mattia Lauriola, David Kain… in Nature Cell Biology (2015)