64 Result(s)
within
Oncology
David J Hunter
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Article
Type of postmenopausal hormone use and risk of breast cancer: 12-year follow-up from the Nurses' Health Study
We prospectively examined the use of hormone replacement therapy in relation to breast cancer incidence in a cohort of women 30 to 55 years of age in 1976. During 12 years of follow-up (480,665 person-years) a...
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Chapter
Dietary Guidelines
There are five-fold differences in breast cancer incidence rates around the world [1], and migrants moving from low- to high-incidence countries acquire rates close to those of the new country after one genera...
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Article
Reproductive factors and family history of breast cancer in relation to plasma estrogen and prolactin levels in postmenopausal women in the Nurses' Health Study (United States)
Parity, age at first birth, age at menarche, and a family history of breast cancer have each been associated consistently with breast cancer risk. Whether this increase in risk is mediated, at least in part, t...
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Article
Nutrition and breast cancer
Epidemiologic evidence on the relation between nutrition and breast cancer is reviewed. After several decades of study, many aspects of the role of diet in breast cancer etiology are still unclear. Results fro...
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Article
Non-dietary factors as risk factors for breast cancer, and as effect modifiers of the association of fat intake and risk of breast cancer
To assess more precisely the relative risks associated with established risk factors for breast cancer, and whether the association between dietary fat and breast cancer risk varies according to levels of thes...
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Article
A prospective study of oral contraceptive use and risk of breast cancer (Nurses' Health Study, United States)
Results of previous epidemiologic studies have provided reassurance that there is little, if any, increase in risk of breast cancer with oral contraceptive (OC) use in general. However, in several studies, an ...
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Article
Polymorphic repeat in AIB1 does not alter breast cancer risk
We assessed the association between a glutamine repeat polymorphism in AIB1 and breast cancer risk in a case-control study (464 cases, 624 controls) nested within the Nurses' Health Study cohort. We observed no a...
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Article
Vitamins and carotenoids intake and the risk of basal cell carcinoma of the skin in women (United States)
Objective: We examined prospectively intakes of vitamins A, C, and E, folate, and specific carotenoids in relation to the risk of basal cell carcinoma of the skin (BCC) in women. Methods: Dietary intake was asse...
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Article
Aspirin, other NSAIDs, and ovarian cancer risk (United States)
Objective: We sought to evaluate the association between ovarian cancer risk and use of aspirin and nonsteroidal anti-inflammatories. Methods: We prospectively assessed use of aspirin, nonsteroidal anti-inflamma...
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Article
Polymorphisms in Steroid Hormone Pathway Genes and Mammographic Density
Mammographic density has been linked with exposure to endogenous and exogenous steroid hormones, and increased breast cancer risk. Variation in breast density may be due, in part, to polymorphisms in steroid h...
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Article
Association of NAT2 and smoking in relation to breast cancer incidence in a population-based case–control study (United States)
Objective: To evaluate the potential interaction between N-acetyltransferase 2 (NAT2) and smoking in breast cancer incidence. Methods: The data are derived from a population-based case–control study of women age...
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Article
Common ataxia telangiectasia mutated haplotypes and risk of breast cancer: a nested case–control study
The ataxia telangiectasia mutated (ATM) gene is a tumor suppressor gene with functions in cell cycle arrest, apoptosis, and repair of DNA double-strand breaks. Based on family studies, women heterozygous for muta...
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Article
Estrogen Receptor β lpar;ESR2) Polymorphisms and Endometrial Cancer (United States)
Objective: We hypothesized that variations in the ESR2 gene may influence estrogen exposure in the uterus and thus influence endometrial cancer risk. We validated and screened for variants in the ESR2 gene and e...
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Article
The progesterone receptor Val660→Leu polymorphism and breast cancer risk
Recent evidence suggests a role for progesterone in breast cancer development and tumorigenesis. Progesterone exerts its effect on target cells by interacting with its receptor; thus, genetic variations, which...
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Article
Open AccessHaplotype analysis of common variants in the BRCA1 gene and risk of sporadic breast cancer
Truncation mutations in the BRCA1 gene cause a substantial increase in risk of breast cancer. However, these mutations are rare in the general population and account for little of the overall incidence of sporadi...
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Article
Open AccessBody fatness during childhood and adolescence and incidence of breast cancer in premenopausal women: a prospective cohort study
Body mass index (BMI) during adulthood is inversely related to the incidence of premenopausal breast cancer, but the role of body fatness earlier in life is less clear. We examined prospectively the relation b...
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Article
Polymorphisms of the AURKA (STK15/Aurora Kinase) Gene and Breast Cancer Risk (United States)
AURKA is an important protein in the regulation of G2 to M transition during mitosis. Due to this regulatory function, it has been hypothesized to be a potential cancer susceptibility gene. Two non-synonymous pol...
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Article
A Pooled Analysis of 12 Cohort Studies of Dietary Fat, Cholesterol and Egg Intake and Ovarian Cancer
Fat and cholesterol are theorized to promote ovarian carcinogenesis by increasing circulating estrogen levels. Although case–control studies have reported positive associations between total and saturated fat ...
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Article
O6-Methylguanine-DNA Methyltransferase Leu84Phe and Ile143Val Polymorphisms and Risk of Colorectal Cancer in the Nurses’ Health Study and Physicians’ Health Study (United States)
O6-methylguanine-DNA methyltransferase (MGMT) removes mutagenic adducts from the O6-position of guanine in DNA. Unrepaired O6-methylguanines result in G:C to A:T transitions in mutated K-ras and p53 in colorectal...
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Article
Open AccessGene × Gene interaction between MnSOD and GPX-1 and breast cancer risk: a nested case-control study
Germ-line mutations in genes such as BRCA1, BRCA2, and ATM can cause a substantial increase in risk of breast cancer. However, these mutations are rare in the general population, and account for little of the inc...
