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Article
Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells
Empirical and anecdotal evidence has associated stress with accelerated hair greying (formation of unpigmented hairs)1,2, but so far there has been little scientific validation of this link. Here we report that, ...
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Article
Open AccessA case of hyperventilation leading to apnea and desaturation in PACU
Respiratory adverse events are not uncommon in the post-anesthesia care unit (PACU) following general anesthesia. In this regard, hyperventilation leading to apnea and desaturation is a rare entity. Here we ha...
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Article
Pain and immunity: implications for host defence
Pain is a hallmark of tissue injury, inflammatory diseases, pathogen invasion and neuropathy. It is mediated by nociceptor sensory neurons that innervate the skin, joints, bones, muscles and mucosal tissues an...
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Chapter and Conference Paper
An Elastic Visco-Plastic Model for Soft Soil with Reference to Radial Consolidation
The time-dependent stress–strain behaviour of soft soil due to its viscous nature affects its long-term settlement and pore water dissipation. A novel mathematical model developed using the Peaceman–Rachford A...
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Chapter
Soft Ground Improvement—Theoretical, Experimental, Numerical and Field Studies
Much of the world’s essential infrastructure is built along congested coastal belts that are composed of weak, highly compressible and low permeable soils to significant depths. Soft alluvial and marine clay h...
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Article
Author Correction: Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia
In the version of this article initially published, the line graph showing TNF-α levels in Fig. 2d was inadvertently duplicated. A graph of IL-6 levels should be shown in place of the duplication.
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Article
Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia
Nociceptor sensory neurons suppress innate immunity during bacterial lung infection.
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Article
Open AccessStaphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314
The hallmark of many bacterial infections is pain. The underlying mechanisms of pain during live pathogen invasion are not well understood. Here, we elucidate key molecular mechanisms of pain produced during l...
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Article
Erratum: The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation
Nature 549, 351–356 (2017); doi:10.1038/nature24029 Owing to a technical error, author Pankaj Baral was listed incorrectly as a corresponding author instead of author Patrick R. Burkett in the HTML version of ...
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Article
The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation
Type 2 innate lymphoid cells (ILC2s) both contribute to mucosal homeostasis and initiate pathologic inflammation in allergic asthma. However, the signals that direct ILC2s to promote homeostasis versus inflamm...
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Article
Open AccessThe use of polymeric and metallic geogrid on a full-scale MSE wall/embankment on hard foundation: a comparison of field data with simulation
A full-scale reinforced earth embankment was designed and constructed by the Department of Highways of Thailand on a hard foundation in Phitsanulok Province, Thailand. Two types of reinforcement were used in t...
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Article
Open AccessHigh prevalence of multidrug resistance in bacterial uropathogens from Kathmandu, Nepal
Urinary Tract Infection (UTI) is one of the most common infectious diseases and people of all age-groups and geographical locations are affected. The impact of disease is even worst in low-resource develo** ...
