-
Article
The crucial p53-dependent oncogenic role of JAB1 in osteosarcoma in vivo
Osteosarcoma (OS) is the most common primary bone cancer and ranks amongst the leading causes of cancer mortality in young adults. Jun activation domain-binding protein 1 (JAB1) is overexpressed in many cancers a...
-
Article
Open AccessAuthor Correction: Early Cellular Responses of Prostate Carcinoma Cells to Sepantronium Bromide (YM155) Involve Suppression of mTORC1 by AMPK
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Open AccessEarly Cellular Responses of Prostate Carcinoma Cells to Sepantronium Bromide (YM155) Involve Suppression of mTORC1 by AMPK
The imidazolium compound YM155, first discovered as a potent inhibitor of Survivin, effectively kills many carcinomas in preclinical models. However, the upstream signaling mechanism triggered by YM155 remains...
-
Article
Neuroendocrine prostate carcinoma cells originate from the p63-expressing basal cells but not the pre-existing adenocarcinoma cells in mice
-
Article
Gene expression profiling of cancer progression reveals intrinsic regulation of transforming growth factor-β signaling in ErbB2/Neu-induced tumors from transgenic mice
Upregulation of HER2/ErbB2/Neu occurs in 15–30% of human breast cancers and correlates with poor prognosis. Identification of ErbB2/Neu transcriptional targets should facilitate development of novel therapeuti...
-
Article
Overexpression of Bax sensitizes prostate cancer cells to TGF-β induced apoptosis
NRP-154 is a tumorigenic epithelial cell line derived from the preneoplastic dorsal-lateral prostate of rats. These cells are exquisitely sensitive to TGF-β induced apoptosis. In contrast, we find that NRP-154...
-
Article
A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif
Here we describe a protein product of the human septin H5/PNUTL2/CDCrel2b gene, which we call ARTS (for apoptosis-related protein in the TGF-β signalling pathway). ARTS is expressed in many cells and acts to e...
-
Protocol
Methods for Iodination of Active TGFβ, TGFβ Receptor Crosslinking and Immunoprecipitation of TGFβ-Receptor Complexes
Radioiodinated transforming growth factors ( TGF-βs) are critical reagents for functional studies on TGF-β ligand-receptor binding (1–5), TGF-β-binding protein interactions (6–9), ligand uptake, degradation and c...
-
Article
Radiation-induced lung injury in vivo: Expression of transforming growth factor—Beta precedes fibrosis
Cytokine release from irradiated cells has been postulated to start soon after irradiation preceding detectable clinical and pathological manifestation of lung injury. The expression of transforming growth fac...
-
Article
Growth of MTW9/PL2 estrogen-responsive rat mammary tumor cells in hormonally defined serum-free media
Growth of the estrogen-responsive MTW9/PL2 rat mammary tumor cells was demonstrated in serum-free defined medium (designated DDM-1) formulated with F12-DME (1:1 vol/vol) supplemented with 15 mM HEPES pH 7.4 insul...
-
Article
Use of serum-free hormonally defined media to evaluate the effects of growth factors and inhibitors on proliferation of estrogen-responsive mammary and pituitary tumor cells in culture
Serum-free defined media have been developed for assay of the mitogenic effects of growth factors on human MCF-7, human T-47D, and mouse COMMA-D mammary cells as well as for identification of mitogens and inhi...
-
Article
New perspectives in hormone-dependent (responsive) and autonomous mammary tumor growth: Role of autostimulatory growth factors
In this report, we present evidence that estrogen-dependent rat mammary tumor cells produce autostimulatory (autocrine) growth factors in response to estrogens, and that hormone autonomous cells produce autorr...
-
Article
Identification of estrogen-inducible growth factors (estromedins) for rat and human mammary tumor cells in culture
The role of polypeptide growth factors (estromedins) as mediators of estrogen-responsive mammary tumor growth is studied in this report. Three possible new mechanisms were investigated that include endocrine, ...
