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Article
Open AccessValidation and real-world clinical application of an artificial intelligence algorithm for breast cancer detection in biopsies
Breast cancer is the most common malignant disease worldwide, with over 2.26 million new cases in 2020. Its diagnosis is determined by a histological review of breast biopsy specimens, which can be labor-inten...
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Article
Open AccessDepression patient-derived cortical neurons reveal potential biomarkers for antidepressant response
Major depressive disorder is highly prevalent worldwide and has been affecting an increasing number of people each year. Current first line antidepressants show merely 37% remission, and physicians are forced ...
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Article
Open AccessLarge-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse
Huntington Disease (HD) is an incurable autosomal dominant neurodegenerative disorder driven by an expansion repeat giving rise to the mutant huntingtin protein (mHtt), which is known to disrupt a multitude of...
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Article
Open AccessBiobanking in Israel 2016–17; expressed perceptions versus real life enrollment
As part of the preparations to establish a population-based biobank in a large Israeli health organization, we aimed to investigate through focus groups the knowledge, perceptions and attitudes of insured Isra...
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Article
Open AccessA pharmacogenetic signature of high response to Copaxone in late-phase clinical-trial cohorts of multiple sclerosis
Copaxone is an efficacious and safe therapy that has demonstrated clinical benefit for over two decades in patients with relapsing forms of multiple sclerosis (MS). On an individual level, patients show variab...
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Article
Open AccessBlood-based identification of non-responders to anti-TNF therapy in rheumatoid arthritis
Faced with an increasing number of choices for biologic therapies, rheumatologists have a critical need for better tools to inform rheumatoid arthritis (RA) disease management. The ability to identify patients...
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Article
Open AccessGene expression studies of a human monocyte cell line identify dissimilarities between differently manufactured glatiramoids
Glatiramer Acetate (GA) has provided safe and effective treatment for multiple sclerosis (MS) patients for two decades. It acts as an antigen, yet the precise mechanism of action remains to be fully elucidated...
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Chapter and Conference Paper
Early Patient Stratification and Predictive Biomarkers in Drug Discovery and Development
The current drug discovery paradigm is long, costly, and prone to failure. For projects in early development, lack of efficacy in Phase II is a major contributor to the overall failure rate. Efficacy failures ...
