-
Article
Open AccessMultiparametric autoantibody analysis: a new paradigm for the diagnosis of connective tissue diseases
In patients affected by connective tissue diseases (CTDs), the identification of wide autoantibody profiles may prove useful in early diagnosis, in the evaluation of prognosis (risk stratification), and in pre...
-
Article
Open AccessEffectiveness and safety of dupilumab in patients with chronic rhinosinusitis with nasal polyps and associated comorbidities: a multicentric prospective study in real life
Biologics are currently one of the main treatment options for a number of diseases. The IgG4 monoclonal antibody dupilumab targets the Interleukin-4 receptor alpha chain, thus preventing the biological effects...
-
Article
Assessment of humoral and cellular immunity induced by the BNT162b2 SARS-CoV-2 vaccine in healthcare workers, elderly people, and immunosuppressed patients with autoimmune disease
The development of vaccines to prevent SARS-CoV-2 infection has mainly relied on the induction of neutralizing antibodies (nAbs) to the Spike protein of SARS-CoV-2, but there is growing evidence that T cell im...
-
Article
Diagnosing and Monitoring Celiac Patients with Selective IgA Deficiency: Still an Open Issue
Although, the association between celiac disease (CD) and selective immunoglobulin A deficiency (SIgAD) has been known for more than fifty years, the procedures for diagnosing and monitoring patients with both...
-
Article
Open AccessCorrection to: Evaluation of a novel particle-based multi-analyte technology for the detection of anti-fibrillarin antibodies
-
Article
Open AccessEvaluation of a novel particle-based multi-analyte technology for the detection of anti-fibrillarin antibodies
Systemic sclerosis (SSc) is a heterogeneous autoimmune disease associated with several anti-nuclear antibodies (ANA), including those in the classification criteria (anti-centromere, anti-topoisomerase I (Scl-...
-
Article
Shrimp-Induced Anaphylaxis
Shrimp and other crustaceans and molluscs are one of the most frequent causes of food allergy and anaphylaxis at all ages. Molecular biology has paved the way to a better understanding of the allergen profile ...
-
Article
Open AccessAnti-DFS70 antibodies detected by specific methods in patients with thrombosis or recurrent pregnancy loss: no evidence of an association
A dense fine speckled pattern (DFS) caused by antibodies to the DFS70 kDa nuclear protein is a relatively common finding while testing for anti-nuclear antibodies (ANA) by indirect immunofluorescence (IIF) on ...
-
Article
House Dust Mite-Shrimp Allergen Interrelationships
Focusing on the strict relationship between house dust mites and crustaceans from the allergenic point of view.
-
Article
Diagnosi di allergia al kiwi in età pediatrica: utilità della diagnostica molecolare
L’allergia al kiwi è attualmente una delle più comuni cause di allergia alimentare e offre un chiaro esempio degli effetti dell’introduzione di un nuovo alimento nella catena alimentare. In recenti studi epide...
-
Article
Choosing Wisely in autoimmunologia: le 5 Proposte del Gruppo di Studio in Autoimmunologia della SIPMeL
Nel novembre 2017, il Gruppo di Studio in Autoimmunologia (GdS-AI) della SIPMeL ha organizzato un convegno nazionale a Santa Margherita Ligure per formulare e discutere alcune proposte per una scelta saggia ne...
-
Article
Open AccessDiagnostic accuracy of a new fluoroenzyme immunoassay for the detection of TSH receptor autoantibodies in Graves’ disease
Thyrotropin receptor (TSHR) autoantibodies (TRAbs) are a hallmark of Graves’ disease (GD). The aim of this study was to evaluate the diagnostic accuracy of a new third generation automatic fluorescence enzyme ...
-
Article
Challenges in the Standardization of Autoantibody Testing: a Comprehensive Review
Standardization and harmonization are complementary tools to achieve higher testing quality in laboratory medicine. Both are of great relevance and are strongly needed in autoimmune diagnostics, due to the imp...
-
Article
Open AccessAbstracts from the Food Allergy and Anaphylaxis Meeting 2016
-
Article
Erratum a: Raccomandazioni per l’utilizzo della diagnostica molecolare in Allergologia
-
Article
Raccomandazioni per l’utilizzo della diagnostica molecolare in Allergologia
Il Gruppo di Studio in Allergologia della Società Italiana di Patologia Clinica e Medicina di Laboratorio (SIPMeL) propone alcune raccomandazioni di diagnostica di laboratorio delle malattie allergiche, basate...
-
Article
Open AccessThe ANA-reflex test as a model for improving clinical appropriateness in autoimmune diagnostics
Reflex tests are widely used in clinical laboratories, for example, to diagnose thyroid disorders or in the follow-up of prostate cancer. Reflex tests for antinuclear antibodies (ANA) have recently gained atte...
-
Article
Open AccessDifferent co-sensitizations could determine different risk assessment in peach allergy? Evaluation of an anaphylactic biomarker in Pru p 3 positive patients
In Italy, the nsLTP (Pru p 3) has been identified as the most frequent cause of food allergy and anaphylaxis. In order to estimate the risk assessment in peach allergy, we investigated the presence of correlat...
-
Article
Raccomandazioni per l’utilizzo del test di attivazione dei basofili nella diagnosi delle malattie allergiche
Il test di attivazione dei basofili (BAT) è un esame di laboratorio che si propone, tramite la valutazione citofluorimetrica di marcatori di attivazione dei basofili, di simulare in vitro un test di scatenamento ...
-
Article
Open AccessEstablishment of the upper reference limit for thyroid peroxidase autoantibodies according to the guidelines proposed by the National Academy of Clinical Biochemistry: comparison of five different automated methods
The estimation of the upper reference limit (URL) for autoantibodies against thyroid peroxidase (TPOAbs) is a controversial issue, because of an uncertainty associated with the criteria used to correctly defin...
