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Article
Open AccessEarly detection of radiation-induced lung damage with X-ray dark-field radiography in mice
Assessing the advantage of x-ray dark-field contrast over x-ray transmission contrast in radiography for the detection of develo** radiation-induced lung damage in mice.
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Article
Open AccessModification of radiosensitivity by Curcumin in human pancreatic cancer cell lines
Pancreatic cancer is one of the most aggressive malignancies and is characterized by a low 5-year survival rate, a broad genetic diversity and a high resistance to conventional therapies. As a result, novel th...
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Article
Selenium does not affect radiosensitivity of breast cancer cell lines
Supplementation with the antioxidant selenium is frequently performed in breast cancer patients to protect the normal tissue from radiation-induced side effects. However, concerns exist whether selenium also p...
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Protocol
Identification of E6/E7-Dependent MicroRNAs in HPV-Positive Cancer Cells
Oncogenic types of human papillomaviruses (HPVs) are closely linked to the development of anogenital and head and neck . The expression of the viral E6 and E7 genes is crucial for the transforming activities of ...
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Article
Open AccessThe MICA-129Met/Val dimorphism affects plasma membrane expression and shedding of the NKG2D ligand MICA
The MHC class I chain-related molecule A (MICA) is a ligand for the activating natural killer (NK) cell receptor NKG2D. A polymorphism causing a valine to methionine exchange at position 129 affects binding to...
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Article
Open AccessNZ28-induced inhibition of HSF1, SP1 and NF-κB triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells
The activity of natural killer (NK) cells is regulated by activating and inhibiting receptors, whereby the C-type lectin natural killer group 2D (NKG2D) receptor serves as the major activating receptor on NK ...
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Article
A hypoxia-induced decrease of either MICA/B or Hsp70 on the membrane of tumor cells mediates immune escape from NK cells
Recent findings suggest that hypoxia of the tumor microenvironment contributes to immune escape from natural killer (NK) cell-mediated cytotoxicity. Heat shock protein 70 (Hsp70) and the stress-regulated major...
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Article
Open AccessHsp70 - a biomarker for tumor detection and monitoring of outcome of radiation therapy in patients with squamous cell carcinoma of the head and neck
Tumor but not normal cells frequently overexpress heat shock protein 70 (Hsp70) and present it on their cell surface (mHsp70) from where it can be actively released. Therefore, membrane (mHsp70) and soluble Hs...
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Article
Radiosensitization of wildtype p53 cancer cells by the MDM2-inhibitor PXN727 is associated with altered heat shock protein 70 (Hsp70) levels
The oncoprotein MDM2 (murine double minute 2) is often overexpressed in human tumors and thereby attenuates the function of the tumor suppressor p53. In this study, we investigated the effects of the novel MDM...
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Article
Open AccessInduction of plasminogen activator inhibitor type-1 (PAI-1) by hypoxia and irradiation in human head and neck carcinoma cell lines
Squamous cell carcinoma of the head and neck (SCCHN) often contain highly radioresistant hypoxic regions, nonetheless, radiotherapy is a common treatment modality for these tumours. Reoxygenation during fracti...
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Chapter and Conference Paper
Compositional Hazard Analysis of UML Component and Deployment Models
The general trend towards complex technical systems with embedded software results in an increasing demand for dependable high quality software. The UML as an advanced object-oriented technology provides in pr...
