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  1. Article

    Open Access

    Combination of tumor asphericity and an extracellular matrix-related prognostic gene signature in non-small cell lung cancer patients

    One important aim of precision oncology is a personalized treatment of patients. This can be achieved by various biomarkers, especially imaging parameters and gene expression signatures are commonly used. So f...

    Sebastian Zschaeck, Bertram Klinger, Jörg van den Hoff, Paulina Cegla in Scientific Reports (2023)

  2. Article

    Open Access

    Integrated radiogenomics analyses allow for subtype classification and improved outcome prognosis of patients with locally advanced HNSCC

    Patients with locally advanced head and neck squamous cell carcinoma (HNSCC) may benefit from personalised treatment, requiring biomarkers that characterize the tumour and predict treatment response. We integr...

    Asier Rabasco Meneghetti, Alex Zwanenburg, Annett Linge in Scientific Reports (2022)

  3. Article

    Open Access

    2D and 3D convolutional neural networks for outcome modelling of locally advanced head and neck squamous cell carcinoma

    For treatment individualisation of patients with locally advanced head and neck squamous cell carcinoma (HNSCC) treated with primary radiochemotherapy, we explored the capabilities of different deep learning a...

    Sebastian Starke, Stefan Leger, Alex Zwanenburg, Karoline Leger in Scientific Reports (2020)

  4. Article

    Open Access

    A comparative study of machine learning methods for time-to-event survival data for radiomics risk modelling

    Radiomics applies machine learning algorithms to quantitative imaging data to characterise the tumour phenotype and predict clinical outcome. For the development of radiomics risk models, a variety of differen...

    Stefan Leger, Alex Zwanenburg, Karoline Pilz, Fabian Lohaus in Scientific Reports (2017)