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Article
Therapie von Lebermetastasen
Die Leber ist einer der Hauptmetastasierungsorte gastrointestinaler, aber auch anderer Malignome. Aus diesem Grunde spielt die Therapie von Lebermetastasen eine zentrale Rolle in der onkologischen Behandlung.
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Article
Open AccessIntegrated radiogenomics analyses allow for subtype classification and improved outcome prognosis of patients with locally advanced HNSCC
Patients with locally advanced head and neck squamous cell carcinoma (HNSCC) may benefit from personalised treatment, requiring biomarkers that characterize the tumour and predict treatment response. We integr...
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Article
Open AccessComparison of the composition of lymphocyte subpopulations in non-relapse and relapse patients with squamous cell carcinoma of the head and neck before, during radiochemotherapy and in the follow-up period: a multicenter prospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG)
Radiochemotherapy (RCT) has been shown to induce changes in immune cell homeostasis which might affect antitumor immune responses. In the present study, we aimed to compare the composition and kinetics of majo...
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Article
Open AccessCorrection: ERCC2 gene single-nucleotide polymorphism as a prognostic factor for locally advanced head and neck carcinomas after definitive cisplatin-based radiochemotherapy
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessERCC2 gene single-nucleotide polymorphism as a prognostic factor for locally advanced head and neck carcinomas after definitive cisplatin-based radiochemotherapy
Identifying patients with locally advanced head and neck carcinoma on high risk of recurrence after definitive concurrent radiochemotherapy is of key importance for the selection for consolidation therapy and ...
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Article
Open AccessMetastasis directed stereotactic radiotherapy in NSCLC patients progressing under targeted- or immunotherapy: efficacy and safety reporting from the ‘TOaSTT’ database
Metastasis directed treatment (MDT) is increasingly performed with the attempt to improve outcome in non-small cell lung cancer (NSCLC) patients receiving targeted- or immunotherapy (TT/IT). This study aimed t...
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Article
Open AccessCorrection to: Predicting survival in melanoma patients treated with concurrent targeted- or immunotherapy and stereotactic radiotherapy
An amendment to this paper has been published and can be accessed via the original article.
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Article
Open Access2D and 3D convolutional neural networks for outcome modelling of locally advanced head and neck squamous cell carcinoma
For treatment individualisation of patients with locally advanced head and neck squamous cell carcinoma (HNSCC) treated with primary radiochemotherapy, we explored the capabilities of different deep learning a...
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Article
Open AccessPredicting survival in melanoma patients treated with concurrent targeted- or immunotherapy and stereotactic radiotherapy
Melanoma patients frequently develop brain metastases. The most widely used score to predict survival is the molGPA based on a mixed treatment of stereotactic radiotherapy (SRT) and whole brain radiotherapy (W...
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Article
Open AccessPSMA-PET based radiotherapy: a review of initial experiences, survey on current practice and future perspectives
68Gallium prostate specific membrane antigen (PSMA) ligand positron emission tomography (PET) is an increasingly used imaging modality in prostate cancer, especially in cases of tumor recurrence after curative i....
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Article
Open AccessImpact of robust treatment planning on single- and multi-field optimized plans for proton beam therapy of unilateral head and neck target volumes
Proton beam therapy is promising for the treatment of head and neck cancer (HNC), but it is sensitive to uncertainties in patient positioning and particle range. Studies have shown that the planning target vol...
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Article
Open AccessA comparative study of machine learning methods for time-to-event survival data for radiomics risk modelling
Radiomics applies machine learning algorithms to quantitative imaging data to characterise the tumour phenotype and predict clinical outcome. For the development of radiomics risk models, a variety of differen...
