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Article
Open AccessAngiosarcoma: clinical outcomes and prognostic factors, a single-center analysis
This study sought to investigate oncological outcomes and prognostic factors for patients with angiosarcomas (AS).
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Article
Open AccessAdjuvant re-irradiation vs. no early re-irradiation of resected recurrent glioblastoma: pooled comparative cohort analysis from two tertiary centers
The optimal management strategy for recurrent glioblastoma (rGBM) remains uncertain, and the impact of re-irradiation (Re-RT) on overall survival (OS) is still a matter of debate. This study included patients ...
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Article
Open AccessValidation of a methylation-based signature for subventricular zone involvement in glioblastoma
Glioblastomas (GBM) with subventricular zone (SVZ) contact have previously been associated with a specific epigenetic fingerprint. We aim to validate a reported bulk methylation signature to determine SVZ cont...
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Article
Open AccessHistopathologically confirmed radiation-induced damage of the brain – an in-depth analysis of radiation parameters and spatio-temporal occurrence
Radiation-induced damage (RID) after radiotherapy (RT) of primary brain tumors and metastases can be challenging to clinico-radiographically distinguish from tumor progression. RID includes pseudoprogression a...
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Article
Open AccessThe role of radiotherapy in the management of malignant peripheral nerve sheath tumors: a single-center retrospective cohort study
This study sought to investigate the role of radiotherapy (RT) in addition to surgery for oncological outcomes in patients with malignant peripheral nerve sheath tumors (MPNST).
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Article
Open AccessCombination of tumor asphericity and an extracellular matrix-related prognostic gene signature in non-small cell lung cancer patients
One important aim of precision oncology is a personalized treatment of patients. This can be achieved by various biomarkers, especially imaging parameters and gene expression signatures are commonly used. So f...
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Article
Open AccessImpact of MRI on target volume definition in head and neck cancer patients
Target volume definition for curative radiochemotherapy in head and neck cancer is crucial since the predominant recurrence pattern is local. Additional diagnostic imaging like MRI is increasingly used, yet it...
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Article
Open AccessPrognostic biomarkers for the response to the radiosensitizer nimorazole combined with RCTx: a pre-clinical trial in HNSCC xenografts
Tumor hypoxia is associated with resistance to radiotherapy and chemotherapy. In head and neck squamous cell carcinoma (HNSCC), nimorazole, an oxygen mimic, combined with radiotherapy (RT) enabled to improve l...
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Article
Open AccessMachine learning identifies multi-parametric functional PET/MR imaging cluster to predict radiation resistance in preclinical head and neck cancer models
Tumor hypoxia and other microenvironmental factors are key determinants of treatment resistance. Hypoxia positron emission tomography (PET) and functional magnetic resonance imaging (MRI) are established progn...
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Article
Open AccessPhoton and Proton irradiation in Patient-derived, Three-Dimensional Soft Tissue Sarcoma Models
Despite their heterogeneity, the current standard preoperative radiotherapy regimen for localized high-grade soft tissue sarcoma (STS) follows a one fits all approach for all STS subtypes. Sarcoma patient-deri...
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Article
Open AccessCorrection : Pulmonary magnetic resonance-guided online adaptive radiotherapy of locally advanced non-small cell lung cancer: the PUMA trial
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Open AccessPulmonary magnetic resonance-guided online adaptive radiotherapy of locally advanced non-small-cell lung cancer: the PUMA trial
Patients with locally-advanced non-small-cell lung cancer (LA-NSCLC) are often ineligible for surgery, so that definitive chemoradiotherapy (CRT) represents the treatment of choice. Nevertheless, long-term tum...
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Article
Open AccessCardiac radioablation of incessant ventricular tachycardia in patients with terminal heart failure under permanent left ventricular assist device therapy—description of two cases
Cardiac radioablation (cRA) using a stereotactic single-session radioablative approach has recently been described as a possible treatment option for patients with otherwise untreatable recurrent ventricular t...
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Article
Open AccessCancer care in German centers of excellence during the first 2 years of the COVID-19 pandemic
An increasing number of international studies demonstrate serious negative effects of the COVID-19 pandemic on the timely diagnosis of cancer and on cancer treatment. Our study aimed to quantitatively and qual...
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Living Reference Work Entry In depth
Kombination von Strahlen- und Chemotherapie
Kombinationen von Strahlentherapie und medikamentöser Therapie (hier im engeren Sinne: Chemotherapie) werden oft eingesetzt. Aus strahlentherapeutischer Sicht sind drei grundsätzlich verschiedene Wirkungsprinz...
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Article
Open AccessPostoperative complications and oncologic outcomes after multimodal therapy of localized high risk soft tissue sarcoma
Standard therapy for localized high-risk soft tissue sarcoma includes surgical resection and neoadjuvant or adjuvant radiation therapy (± chemotherapy and locoregional hyperthermia). No difference in oncologic...
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Article
Open AccessSarcoma classification by DNA methylation profiling in clinical everyday life: the Charité experience
Sarcomas are a heterogeneous group of rare malignant tumors with more than 100 subtypes. Accurate diagnosis remains challenging due to a lack of characteristic molecular or histomorphological hallmarks. A DNA ...
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Article
Open AccessIntegrated radiogenomics analyses allow for subtype classification and improved outcome prognosis of patients with locally advanced HNSCC
Patients with locally advanced head and neck squamous cell carcinoma (HNSCC) may benefit from personalised treatment, requiring biomarkers that characterize the tumour and predict treatment response. We integr...
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Article
Open AccessEx vivo γH2AX assay for tumor radiosensitivity in primary prostate cancer patients and correlation with clinical parameters
Accurate surrogate parameters for radio resistance are warranted for individualized radiotherapy (RT) concepts in prostate cancer (PCa). The purpose of this study was to assess intertumoral heterogeneity in te...
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Article
Open AccessFisetin induces DNA double-strand break and interferes with the repair of radiation-induced damage to radiosensitize triple negative breast cancer cells
Triple-negative breast cancer (TNBC) is associated with aggressiveness and a poor prognosis. Besides surgery, radiotherapy serves as the major treatment modality for TNBC. However, response to radiotherapy is ...
