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Chapter
Receptor Tyrosine Kinases: Principles and Functions in Glioma Invasion
Protein tyrosine kinases are enzymes that are capable of adding a phosphate group to specific tyrosines on target proteins. A receptor tyrosine kinase (RTK) is a tyrosine kinase located at the cellular membran...
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Article
Contribution of sellar dura integrity to symptom manifestation in pituitary adenomas with intratumoral hemorrhage
Although hemorrhage within pituitary adenomas frequently exacerbates the symptoms, there are many grades of severity. Moreover, the contributing factors for symptom severity are still controversial.
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Article
Prediction of postoperative diabetes insipidus using morphological hyperintensity patterns in the pituitary stalk on magnetic resonance imaging after transsphenoidal surgery for sellar tumors
Diabetes insipidus (DI) remains a complication of transsphenoidal surgery (TSS) for sellar and parasellar tumors. Antidiuretic hormone (ADH) appears as hyper intensity (HI) in the pituitary stalk and the poste...
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Article
Pediatric symptomatic Rathke cleft cyst compared with cystic craniopharyngioma
Symptomatic Rathke cleft cysts (RCCs) are rarely detected in neuroradiological screening and are less commonly found in children than in adults. However, when RCCs are observed in children, it is important to ...
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Article
Simultaneous ventriculoperitoneal shunt removal and endoscopic third ventriculostomy for three patients previously treated for intracranial germ cell tumors more than 20 years ago
Obstructive hydrocephalus is the most common complication of intracranial germ cell tumors (IGCTs). Although ventriculoperitoneal shunts (VPSs) were previously used for treating this condition, they have recen...
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Article
Significant improvement of intractable headache after transsphenoidal surgery in patients with pituitary adenomas; preoperative neuroradiological evaluation and intraoperative intrasellar pressure measurement
Headache is the most common symptom of both primary and metastatic brain tumor, and is generally considered the primary symptom in patients with large pituitary adenomas. However, patients with small pituitary...
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Article
Open AccessComparison between pre-operative MRI and intra-operative endoscopic findings for idiopathic normal pressure hydrocephalus
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Article
Detection of the development of late-onset idiopathic aqueductal stenosis (LIAS) by chronological magnetic resonance imaging: a case report
Late-onset idiopathic aqueductal stenosis (LIAS) has been recognized as one of the clinical entities of adulthood hydrocephalus for decades, although there have been no radiological reports that show normal ve...
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Article
The mechanism of chemoresistance against tyrosine kinase inhibitors in malignant glioma
Glioblastoma (GBM) is one of the most lethal malignancies in humans, and novel therapeutic strategies are urgently required for its treatment. Tyrosine kinases (TKs) play a pivotal role in intercellular signal...
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Chapter
Signaling Cascades Driving the Malignant Phenotype of Glioma Cells
The most malignant brain tumor glioblastoma multiforme (GBM) is characterized by exponential growth and diffuse invasiveness. These characteristics are attributed to the varieties of common genetic lesions in gen...
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Chapter
Receptor Tyrosine Kinases: Principles and Functions in Glioma Invasion
Protein tyrosine kinases are enzymes that are capable of adding a phosphate group to specific tyrosines on target proteins. A receptor tyrosine kinase (RTK) is a tyrosine kinase located at the cellular membran...
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Article
The expression level of sphingosine-1-phosphate receptor type 1 is related to MIB-1 labeling index and predicts survival of glioblastoma patients
Although there are many reports on the clinical use of the MIB-1 labeling index (LI), which is a measure of proliferative activity in astrocytomas; its significance varies between studies. There are no known m...
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Chapter
RNAi in Malignant Brain Tumors: Relevance to Molecular and Translational Research
Gliomas are the most frequent malignant intracranial tumors arising from the brain or spinal cord tissue. The most malignant among them is glioblastoma multiforme (GBM), which constitutes approximately 20–25% ...
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Article
PIK3CA alterations in primary (de novo) and secondary glioblastomas
We assessed alterations in the EGFR/PTEN/PI3K pathway in 107 primary (de novo) glioblastomas and 32 secondary glioblastomas that progressed from low-grade or anaplastic astrocytomas. SSCP followed by DNA seque...
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Article
Human glioblastomas overexpress ADAMTS-5 that degrades brevican
Selective cleavage of the Glu395-Ser396 bond of brevican, one of the major proteoglycans in adult brain tissues, is thought to be important for glioma cell invasion. Our previous biochemical study demonstrated th...
