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Contribution of sellar dura integrity to symptom manifestation in pituitary adenomas with intratumoral hemorrhage

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Abstract

Purpose

Although hemorrhage within pituitary adenomas frequently exacerbates the symptoms, there are many grades of severity. Moreover, the contributing factors for symptom severity are still controversial.

Methods

This retrospective study included 82 patients who underwent transsphenoidal surgery for pituitary adenomas with intratumoral hemorrhage. The grades of preoperative symptoms were classified into group A, asymptomatic or minor symptoms; group B, moderate symptoms sufficient for complain; and group C, severe symptoms disturbing daily life.

Results

The hemorrhage volume within an adenoma was significantly higher in group C (92.6%) than in groups A (48.6%) and B (58.7%). Both headache and diplopia were dominant in group C, occurring in 72.2% and 27.8% of the patients, respectively. In group C, there was no significant difference in frequency between adenoma extensions into the sphenoid sinus (0%) and involvement of the cavernous sinus of Knosp grade 4 (0%), and extensions into the suprasellar region were not common (38.9%). The most distinctive feature was that “no extrasellar extension” was found only in group C (41.2%), and “multidirectional extension” was not detected in this group (0%). Multiple regression analysis revealed that the most powerful determining factors were the high frequencies of intratumoral hemorrhage and lack of extrasellar and multidirectional extensions.

Conclusion

Rapid volume expansion of a hematoma and lack of extension or unidirectional extension might lead to significant compression of the sellar and surrounding structures. Of note, the integrity of the sellar dura might contribute to the acute onset of symptom manifestations caused by hemorrhage in pituitary adenomas.

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Abbreviations

CT:

Computed tomography

MRI:

Magnetic resonance imaging

TSS:

Transsphenoidal surgery

WI:

Weighted image

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Authors and Affiliations

  1. Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan

    Yasuhiko Hayashi, Yasuo Sasagawa, Daisuke Kita, Issei Fukui, Masahiro Oishi & Mitsutoshi Nakada

  2. Department of Neurosurgery, Kanazawa Medical University, Kanazawa, Japan

    Osamu Tachibana

  3. Department of Radiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan

    Fumiaki Ueda

Authors
  1. Yasuhiko Hayashi
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  2. Yasuo Sasagawa
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  3. Daisuke Kita
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  4. Issei Fukui
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  5. Masahiro Oishi
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  6. Osamu Tachibana
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  7. Fumiaki Ueda
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  8. Mitsutoshi Nakada
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Correspondence to Yasuhiko Hayashi.

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Hayashi, Y., Sasagawa, Y., Kita, D. et al. Contribution of sellar dura integrity to symptom manifestation in pituitary adenomas with intratumoral hemorrhage. Pituitary 20, 531–538 (2017). https://doi.org/10.1007/s11102-017-0814-x

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  • DOI: https://doi.org/10.1007/s11102-017-0814-x

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