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Article
Bacoside a inhibits the growth of glioma by promoting apoptosis and autophagy in U251 and U87 cells
Bacoside A (gypenoside, Gyp) is a potent bioactive compound derived from Gynostemma pentaphyllum, known to exert inhibitory effects on various malignant tumors. However, the effects of Gyp on glioma as well as th...
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Article
Open AccessInhibition of Endoplasmic Reticulum Stress Improves Chronic Ischemic Hippocampal Damage Associated with Suppression of IRE1α/TRAF2/ASK1/JNK-Dependent Apoptosis
Chronic cerebral ischemia is a complex form of stress, of which the most common hemodynamic characteristic is chronic cerebral hypoperfusion (CCH). Lasting endoplasmic reticulum (ER) stress can drive neurologi...
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Article
Open AccessAlleviating CB2-Dependent ER Stress and Mitochondrial Dysfunction Improves Chronic Cerebral Hypoperfusion-Induced Cognitive Impairment
Augmentation of endoplasmic reticulum (ER) stress may trigger excessive oxidative stress, which induces mitochondrial dysfunction. The fatty acid amide hydrolase inhibitor, URB597, shows...
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Article
Open AccessFecal microbiota transplantation and replenishment of short-chain fatty acids protect against chronic cerebral hypoperfusion-induced colonic dysfunction by regulating gut microbiota, differentiation of Th17 cells, and mitochondrial energy metabolism
Little is known about the association between gut microbiota and intestinal injury under a state of chronic cerebral hypoperfusion (CCH). Here, the effects of gut microbiota and short-chain fatty acids (SCFAs)...
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Chapter and Conference Paper
The Stam** Process and Die Design of Fender Based on Three-Step
It introduced a stam** process based on three-step of fender, in order to reduce the quantity of dies, and decrease the tooling investment. The product characteristic, stam** formability, and die structure...
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Article
The Cannabinoid Receptor Agonist WIN55,212-2 Ameliorates Hippocampal Neuronal Damage After Chronic Cerebral Hypoperfusion Possibly Through Inhibiting Oxidative Stress and ASK1-p38 Signaling
Chronic cerebral hypoperfusion (CCH) is a major contributor to cognitive decline and degenerative processes leading to Alzheimer’s disease, vascular dementia, and aging. However, the delicate mechanism of CCH-...
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Article
Open AccessURB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion
Previous studies reported that URB597 (URB) had therapeutic potential for treating chronic cerebral hypoperfusion (CCH)-induced neuroinflammation and autophagy dysfunction. However, the interaction mechanisms ...
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Article
Andrographolide enhances hippocampal BDNF signaling and suppresses neuronal apoptosis, astroglial activation, neuroinflammation, and spatial memory deficits in a rat model of chronic cerebral hypoperfusion
Andrographolide is a medical herbal compound with documented anti-inflammatory activity and therapeutic efficacy in animal models of Alzheimer’s disease, traumatic brain injury, and ischemic stroke. The presen...
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Article
Open AccessThermodynamically stable whilst kinetically labile coordination bonds lead to strong and tough self-healing polymers
There is often a trade-off between mechanical properties (modulus and toughness) and dynamic self-healing. Here we report the design and synthesis of a polymer containing thermodynamically stable whilst kineti...
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Article
Open AccesscircHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA
Myofibroblasts predominantly emerging through fibroblast-to-myofibroblast transition (FMT) are considered to be the key collagen-producing cells in pulmonary fibrosis. Circular RNAs (circRNAs) are important pl...
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Article
Open AccessA rigid and healable polymer cross-linked by weak but abundant Zn(II)-carboxylate interactions
Achieving a desirable combination of solid-like properties and fast self-healing is a great challenge due to slow diffusion dynamics. In this work, we describe a design concept that utilizes weak but abundant ...
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Article
Open AccessInhibition of excessive autophagy and mitophagy mediates neuroprotective effects of URB597 against chronic cerebral hypoperfusion
URB597 (URB) has therapeutic potential for treating chronic cerebral hypoperfusion (CCH)-induced neuronal death. The present study investigated the protective effects of URB on autopahgy and mitophagy in a CCH...
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Chapter and Conference Paper
Investigation on Induction Hardening Treatment of Cylindrical Drive Gear Shaft
The feasibility of applying induction hardening treatment in the production of cylindrical drive gear shaft, which is made of medium carbon low alloy steel and used in heavy duty tandem bridge, is investigated...
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Article
Interaction between poly (ethylene oxide) and silica nanoparticles in dilute solutions
A mixed system that includes poly(ethylene oxide) (PEO) and silica (SiO2) nanoparticles is prepared using two mixing methods. The interaction between PEO and the SiO2 nanoparticles in the dilute basic solution is...
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Article
Adsorption-desorption of silica nanoparticles on poly(ethylene glycol) brushes grafted onto au substrate studied by quartz crystal microbalance
The adsorption-desorption of silica nanoparticles(NPs) on poly(ethylene glycol)(PEG) grafted onto gold(Au) substrate was studied by quartz crystal microbalance with dissipation monitoring(QCM-D) technique. The...
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Article
Open Accessγ-MYN: a new algorithm for estimating Ka and Ks with consideration of variable substitution rates
Over the past two decades, there have been several approximate methods that adopt different mutation models and used for estimating nonsynonymous and synonymous substitution rates (Ka and Ks) based on protein-...
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Article
Improved electrical insulation of rare earth permanent magnetic materials with high magnetic properties
Rare earth permanent magnetic materials are typical electrical conductor, and their magnetic properties will decrease because of the eddy current effect, so it is difficult to keep them stable for a long enoug...
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Article
Immunohistochemical analysis of p53 protein over-expression in endometrial carcinomas: Inverse correlation with sex steroid receptor status
Mutations of the tumour suppressor p53 gene have been reported in a variety of human malignant tumours, and are frequently associated with over-expression of p53 protein. To examine the significance of p53 gen...
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Article
Immunohistochemical localization of c-erbB-2 protein and epidermal growth factor receptor in normal surface epithelium, surface inclusion cysts, and common epithelial tumours of the ovary
The c-erbB-2 (HER-2/neu) protein is a membrane glycoprotein growth factor receptor showing molecular homology with the epidermal growth factor receptor (EGFR). We examined the immunohistochemical reactivity of mo...
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Article
Expression of c-erbB-2 protein and epidermal growth factor receptor in normal tissues of the female genital tract and in the placenta
The c-erbB-2 (HER-2/neu) protein is a membrane glycoprotein growth factor receptor that has molecular homology with the epidermal growth factor receptor (EGFR). To investigate the relationship between the express...
