5 Result(s)
within
D. Tibboel
Biomedicine
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Article
Open AccessScaling Drug Clearance from Adults to the Young Children for Drugs Undergoing Hepatic Metabolism: A Simulation Study to Search for the Simplest Scaling Method
Previous research showed that scaling drug clearance from adults to children based on body weight alone is not accurate for all hepatically cleared drugs in very young children. This study systematically asses...
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Article
Open AccessPopulation pharmacokinetics of haloperidol in terminally ill adult patients
Over 80% of the terminally ill patients experience delirium in their final days. In the treatment of delirium, haloperidol is the drug of choice. Very little is known about the pharmacokinetics of haloperidol ...
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Article
O-demethylation of tramadol in the first months of life
Assess in vivo O-demethylation activity in the first months of life.
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Article
Tramadol concentrations in blood and in cerebrospinal fluid in a neonate
Based on blood and cerebrospinal fluid samples collected in a full-term neonate, the penetration of tramadol in the central nervous system is described. Following intravenous administration of tramadol, a lag ...
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Article
Acetaminophen in cerebrospinal fluid in children
There are few studies describing acetaminophen (APAP) cerebrospinal fluid (CSF) concentrations in children. This current study was undertaken in children—from neonates to adolescents—in order to investigate ag...
