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Article
Open AccessNon-Invasive MRI of Blood–Cerebrospinal Fluid Barrier Function
The blood–cerebrospinal fluid barrier (BCSFB) is a highly dynamic transport interface that serves brain homeostasis. To date, however, understanding of its role in brain development and pathology has been hind...
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Article
Genetic basis for variation in plasma IL-18 levels in persons with chronic hepatitis C virus and human immunodeficiency virus-1 infections
Inflammasomes are multi-protein complexes integrating pathogen-triggered signaling leading to the generation of pro-inflammatory cytokines including interleukin-18 (IL-18). Hepatitis C virus (HCV) and human im...
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Article
Open AccessDisrupted habenula function in major depression
The habenula is a small, evolutionarily conserved brain structure that plays a central role in aversive processing and is hypothesised to be hyperactive in depression, contributing to the generation of symptom...
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Article
Genome-wide association study of hepatitis C virus- and cryoglobulin-related vasculitis
The host genetic basis of mixed cryoglobulin vasculitis is not well understood and has not been studied in large cohorts. A genome-wide association study was conducted among 356 hepatitis C virus (HCV) RNA-pos...
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Article
Admixture analysis of spontaneous hepatitis C virus clearance in individuals of African descent
Hepatitis C virus (HCV) infects an estimated 3% of the global population with the majority of individuals (75–85%) failing to clear the virus without treatment, leading to chronic liver disease. Individuals of...
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Article
Hip bone geometry in HIV/HCV-co-infected men and healthy controls
People with both HIV and hepatitis C are more likely than those with HIV alone to have wrist, hip, and spine fractures. We compared hip strength between HIV/HCV-co-infected men and healthy men and found that H...
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Article
An efficient rHSV-based complementation system for the production of multiple rAAV vector serotypes
Recombinant herpes simplex virus type 1 (rHSV)-assisted recombinant adeno-associated virus (rAAV) vector production provides a highly efficient and scalable method for manufacture of clinical grade rAAV vector...
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Article
Evaluation of on-farm irrigation applications using the simulation model EPIC
An understanding of water needs in agriculture is a critical input in resolving the water resource issues that confront many southeastern and other US states. The objective of this study was to evaluate on-far...
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Article
Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance
Hepatitis C virus (HCV) is an infectious blood-borne pathogen that usually persists as a chronic infection. However, approximately 15% of the time, patients can clear the virus, indicating that host difference...
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Article
Predicting Cotton Lint Yield Maps from Aerial Photographs
It is generally accepted that aerial images of growing crops provide spatial and temporal information about crop growth conditions and may even be indicative of crop yield. The focus of this study was to devel...
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Article
An analysis of tumor necrosis factor α gene polymorphisms and haplotypes with natural clearance of hepatitis C virus infection
The cytokine tumor necrosis factor alpha (TNF-α) is important in generating an immune response against a hepatitis C virus (HCV) infection. The functions of TNF-α may be altered by single-nucleotide polymorphi...
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Article
MICA and recovery from hepatitis C virus and hepatitis B virus infections
The polymorphic MHC class I chain-related A (MICA) gene encodes a ligand that has different binding affinities for the NKG2D activating receptor of CD8+ T cells and natural killer (NK) cells. We hypothesized t...
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Chapter
Hepatitis C Epidemiology
More than 170 million individuals in virtually every area of the world have hepatitis C virus (HCV) infection. HCV is most often transmitted by percutaneous exposure to blood. However, the predominant modes of...
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Chapter and Conference Paper
HI in HII-Galaxies and Their Companions
HII galaxies are dwarf galaxies which are currently actively forming stars. We speculated that an interaction with an optically faint, but gas-rich object might be responsible for their enhanced star formation...
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Chapter
Enhancement of Hydroxyl Radical Induced Methionine Oxidation to Methionine Sulfoxide by the Vitamin E Analogue Trolox C
Vitamin E is involved in the protection of cellular membranes against lipid peroxidation by scavenging free oxygen centered radicals (1,2), e.g. in the general reaction.
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Article
A vectorcardiograph for assessing implanted cardiac pacemakers
A pacemaker vectorcardiograph for the assessment of all makes and types of implanted cardiac pacemaker is described. Simultaneous measurement on conventional limb leads is employed and direct display on an osc...
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Article
Improvements in the technique of assessing implanted cardiac pacemakers
Over 250 pacemaker patients currently attend pacemaker clinics in three Glasgow hospitals. Since 1968, the pacemaker frontal-plane vector technique has been used at these clinics along with other investigation...
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Chapter
Intra-Partum Monitoring: An Obstetrician’s View and a Physicist’s Response
In 1969 at the Southern General Hospital, an investigation was started to review foetal heart monitoring equipment for the new Maternity Unit. This review was conducted in collaboration with the Department of ...
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Article
A pacemaker digital electrocardiograph for accurate measurements of pacemaker pulse amplitude, width and rate in the assessment of implanted cardiac pacemakers
During the past 8 yr over 170 patients in the Glasgow area have received cardiac pacemaker implants. All such patients attend pacemaker clinics at which both clinical and electronic examinations are carried ou...
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Article
A pacemaker digital electrocardiograph for accurate assessment of implanted cardiac pacemakers
During the past 8 yr over 170 patients in the Glasgow area have received cardiac pacemaker implants. All such patients attend pacemaker clinics at which both clinical and electronic examinations are carried ou...
