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  1. Article

    Open Access

    Sensitive detection of mitochondrial DNA variants for analysis of mitochondrial DNA-enriched extracts from frozen tumor tissue

    Large variation exists in mitochondrial DNA (mtDNA) not only between but also within individuals. Also in human cancer, tumor-specific mtDNA variation exists. In this work, we describe the comparison of four m...

    M. J. A. Weerts, E. C. Timmermans, R. H. A. M. Vossen, D. van Strijp… in Scientific Reports (2018)

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  2. Article

    Open Access

    Complete sequence-based pathway analysis by differential on-chip DNA and RNA extraction from a single cell

    We demonstrate on-chip, differential DNA and RNA extraction from a single cell using a microfluidic chip and a two-stage lysis protocol. This method enables direct use of the whole extract, without additional ...

    D. van Strijp, R. C. M. Vulders, N. A. Larsen, J. Schira… in Scientific Reports (2017)

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  3. Article

    Open Access

    Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG-positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression

    There is an acute need to uncover biomarkers that reflect the molecular pathologies, underpinning prostate cancer progression and poor patient outcome. We have previously demonstrated that in prostate cancer c...

    R Böttcher, D J P Henderson, K Dulla, D van Strijp… in British Journal of Cancer (2015)

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