71 Result(s)

Article

EEG asymmetries may be affected by cranial and Brain parenchymal asymmetries

The plagiocephaly index, an index that reflects an underlying anatomic asymmetry of the brain, was assessed in ten schizophrenic patients and its values were correlated with the lateral distribution of quantit...

M. S. Myslobodsky, R. Coppola, J. Bar-Ziv, C. Karson, D. Daniel… in Brain Topography (1989)

Chapter and Conference Paper

Brain Anatomy in Schizophrenia: Discussion

I would like to begin my discussion by congratulating Drs. Bogerts, Gattaz, and Nasrallah for excellent reviews of recent developments in the study of anatomical deviations in the brains of patients with schiz...

D. R. Weinberger in Search for the Causes of Schizophrenia (1991)

Chapter and Conference Paper

Structural Brain Changes in Schizophrenia: The Issue of Subgroups

Developments in modern neuroimaging techniques have significantly advanced our ability to examine brain structures in living subjects. As a result, replicable neuropathological changes have been demonstrated i...

L. Marsh, D. R. Weinberger in Imaging of the Brain in Psychiatry and Related Fields (1993)

Article

Autoradiographic characterization of neurotensin receptors in the entorhinal cortex of schizophrenic patients and control subjects

Neurotensin, an endogenous peptide and putative neurotransmitter, exhibits a wide range of interactions with dopaminergic neurons and displays some actions akin to neuroleptics. Moreover, neurotensin receptors...

S. S. Wolf, T. M. Hyde, R. C. Saunders… in Journal of Neural Transmission / General S… (1995)

Article

Persistent catalepsy associated with severe dyskinesias in rats treated with chronic injections of haloperidol decanoate

Patients who develop persistent parkinsonism while on chronic neuroleptic therapy may be predisposed towards the development of tardive dyskinesia (TD). We investigated this issue in an animal model of TD by e...

T. M. Hyde, D. R. Weinberger, J. E. Kleinman, M. F. Egan, L. L. Wing… in Psychopharmacology (1995)

Article

Differential cholinergic regulation in Alzheimer's patients compared to controls following chronic blockade with scopolamine: a SPECT study

The effects of low-dose chronic scopolamine on measures of cerebral perfusion and muscarinic receptors were tested in eight Alzheimer's disease (AD) subjects and eight elderly controls. Single photon emission ...

T. Sunderland, G. Esposito, S. E. Molchan, R. Coppola, D. W. Jones… in Psychopharmacology (1995)

Article

Increased sensitivity to the sensorimotor gating-disruptive effects of apomorphine after lesions of medial prefrontal cortex or ventral hippocampus in adult rats

Sensorimotor gating of the startle reflex is impaired in humans with schizophrenia and in rats after mesolimbic D₂ dopamine receptor activation. The loss of startle gating after D₂ activation in rats has been use...

N. R. Swerdlow, D. L. Braff, M. A. Geyer, B. K. Lipska… in Psychopharmacology (1995)

Article

Neonatal excitotoxic hippocampal damage in rats causes post-pubertal changes in prepulse inhibition of startle and its disruption by apomorphine

Neonatal excitotoxic hippocampal damage in the rat results in postpubertal onset of a variety of abnormal behaviors related to excessive dopaminergic transmission in the mesolimbic/nigrostriatal system, and th...

B. K. Lipska, D. R. Weinberger, N. R. Swerdlow, M. A. Geyer… in Psychopharmacology (1995)

Article

Prodynorphin mRNA expression is increased in the patch vs matrix compartment of the caudate nucleus in suicide subjects

Experimental and clinical studies suggest an involvement of the opioid neuropeptide system in psychiatric disorders. Notably, opioid peptide immunoreactivity is altered in the cerebrospinal fluid of chronic sc...

Y L Hurd, M M Herman, T M Hyde, L B Bigelow, D R Weinberger… in Molecular Psychiatry (1997)

Article

Attenuated extracellular dopamine levels after stress and amphetamine in the nucleus accumbens of rats with neonatal ventral hippocampal damage

In vivo microdialysis was used to study the effects of restraint stress (30 min) and amphetamine (AMPH) (5 mg/kg, i.p.) in awake adult male rats with neonatal ventral hippocampal (VH) damage. Extracellular le...

S. M. Lillrank, B. K. Lipska, B. S. Kolachana… in Journal of Neural Transmission (1999)

Chapter

Schizophrenie: Die neurobiologische Entwicklungshypothese

Kraepelin faßte die Schizophrenie als eine frühzeitige Demenz auf, die in der 2. oder 3. Lebensdekade auftritt und sich im Verlauf der Erkrankung verschlechtert (Kraepelin 1899). Sowohl Bleuler (1911) als auch...

A. Heinz, D. R. Weinberger in Psychiatrie der Gegenwart 5 (2000)

Chapter

Schizophrenia: The Neurodevelopmental Hypothesis

Kraepelin conceptualized schizophrenia as a premature dementia, presenting in the second or third decade of life and deteriorating over the course of the illness (Kraepelin 1899). Both Bleuler (1911) and Kraep...

A. Heinz, D. R. Weinberger in Contemporary Psychiatry (2001)

Article

Developmental and stress-related changes of neurotrophic factor gene expression in an animal model of schizophrenia

The neonatal (PND 7) lesion of the ventral hippocampus (VH) with ibotenic acid represents a well-established experimental paradigm that recapitulates many schizophrenia-like phenomena. In order to investigate ...

R Molteni, B K Lipska, D R Weinberger, G Racagni, M A Riva in Molecular Psychiatry (2001)

Article

Serotonin transporter availability correlates with alcohol intake in non-human primates

A low level of alcohol intoxication upon initial exposure and impulsive aggressiveness predispose humans to alcoholism. In non-human primates, central serotonin transporter availability and turnover rate were ...

A Heinz, D W Jones, J G Gorey, A Bennet, S J Suomi, D R Weinberger… in Molecular Psychiatry (2003)

Article

Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia

Anatomical and molecular abnormalities of excitatory neurons in the dorsolateral prefrontal cortex (DLPFC) are found in schizophrenia. We hypothesized that brain-derived neurotrophic factor (BDNF), a protein c...

C S Weickert, T M Hyde, B K Lipska, M M Herman, D R Weinberger… in Molecular Psychiatry (2003)

Article

Presynaptic proteins in the prefrontal cortex of patients with schizophrenia and rats with abnormal prefrontal development

Dysfunction of the prefrontal cortex in schizophrenia may be associated with abnormalities in synaptic structure and/or function and reflected in altered concentrations of proteins in presynaptic terminals and...

N D Halim, C S Weickert, B W McClintock, T M Hyde, D R Weinberger… in Molecular Psychiatry (2003)

Article

Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia

Genetic linkage and association have implicated neuregulin-1 (NRG-1) as a schizophrenia susceptibility gene. We measured mRNA expression levels of the three major isoforms of NRG-1 (ie type I, type II, and typ...

R Hashimoto, R E Straub, C S Weickert, T M Hyde, J E Kleinman… in Molecular Psychiatry (2004)

Article

Schizophrenia genes within cortical neural circuits

P J Harrison, D R Weinberger in Molecular Psychiatry (2005)

Article

Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence

This review critically summarizes the neuropathology and genetics of schizophrenia, the relationship between them, and speculates on their functional convergence. The morphological correlates of schizophrenia ...

P J Harrison, D R Weinberger in Molecular Psychiatry (2005)