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  1. Article

    Open Access

    Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system

    Metastatic outgrowth in breast cancer can occur years after a seeming cure. Existing model systems of dormancy are limited as they do not recapitulate human metastatic dormancy without exogenous manipulations ...

    S E Wheeler, A M Clark, D P Taylor, C L Young, V C Pillai… in British Journal of Cancer (2014)

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  2. No Access

    Article

    Bifunctional compounds for targeted hepatic gene delivery

    A series of bifunctional compounds with galactosyl residues as targeting ligand for asialoglycoprotein receptors on hepatocytes and various dendrimers as the DNA-binding domain was synthesized. When mixed with...

    K S Kim, Y Lei, D B Stolz, D Liu in Gene Therapy (2007)

  3. Article

    Open Access

    Co-culturing human prostate carcinoma cells with hepatocytes leads to increased expression of E-cadherin

    Metastasis is a multi-step process wherein tumour cells detach from the primary mass, migrate through barrier matrices, gain access to conduits to disseminate, and subsequently survive and proliferate in an ec...

    C C Yates, C R Shepard, D B Stolz, A Wells in British Journal of Cancer (2007)

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  4. No Access

    Article

    Structural impact of hydrodynamic injection on mouse liver

    The impact of hydrodynamic injection on liver structure was evaluated in mice using various microscopic techniques. Upon hydrodynamic injection of approximately 9% of body weight by volume, the liver rapidly e...

    T Suda, X Gao, D B Stolz, D Liu in Gene Therapy (2007)

  5. No Access

    Article

    Hydroporation as the mechanism of hydrodynamic delivery

    We have reported that a rapid tail vein injection of a large volume of plasmid DNA solution into a mouse results in high level of transgene expression in the liver. Gene transfer efficiency of this hydrodynami...

    G Zhang, X Gao, Y K Song, R Vollmer, D B Stolz, J Z Gasiorowski, D A Dean… in Gene Therapy (2004)