51 Result(s)

Article

Catechol O-Methyltransferase (COMT) mRNA Expression in the Dorsolateral Prefrontal Cortex of Patients with Schizophrenia

Human prefrontal cortical neurons express catechol O-methyltransferase (COMT), an enzyme that inactivates the neurotransmitter dopamine. A functional polymorphism of COMT, Val^108/158 Met, affects prefrontal funct...

Mitsuyuki Matsumoto, Cynthia Shannon Weickert, Senda Beltaifa… in Neuropsychopharmacology (2003)

Article

Glutamate Carboxypeptidase II Gene Expression in the Human Frontal and Temporal Lobe in Schizophrenia

There is decreased activity of glutamate carboxypeptidase II (GCP II) in the dorsolateral prefrontal cortex (DLPFC) and hippocampus of patients with schizophrenia. GCP II hydrolzses N-acetyl-α L-aspartyl-L-glutam...

Subroto Ghose, Cynthia Shannon Weickert, Sarah M Colvin… in Neuropsychopharmacology (2004)

Article

Effects of Chronic Haloperidol and Clozapine Treatment on Neurogenesis in the Adult Rat Hippocampus

It has been proposed that the therapeutic benefits of treatment with antidepressants and mood stabilizers may arise partially from their ability to stimulate neurogenesis. This study was designed to examine th...

Nader D Halim, Cynthia Shannon Weickert, Benjamin W McClintock… in Neuropsychopharmacology (2004)

Article

Gene expression in the prefrontal cortex during adolescence: implications for the onset of schizophrenia

Many critical maturational processes take place in the human brain during postnatal development. In particular, the prefrontal cortex does not reach maturation until late adolescence and this stage is associat...

Laura W Harris, Helen E Lockstone, Phillipp Khaitovich… in BMC Medical Genomics (2009)

Article

Abnormal Glucocorticoid Receptor mRNA and Protein Isoform Expression in the Prefrontal Cortex in Psychiatric Illness

Stress has been implicated in the onset and illness course of schizophrenia and bipolar disorder. The effects of stress in these disorders may be mediated by abnormalities of the hypothalamic–pituitary–adrenal...

Duncan Sinclair, Shan Yuan Tsai, Heng Giap Woon… in Neuropsychopharmacology (2011)

Article

Glucocorticoid receptor mRNA and protein isoform alterations in the orbitofrontal cortex in schizophrenia and bipolar disorder

The orbitofrontal cortex (OFC) may play a role in the pathogenesis of psychiatric illnesses such as bipolar disorder and schizophrenia, in which hypothalamic-pituitary-adrenal (HPA) axis abnormalities are obse...

Duncan Sinclair, Maree J Webster, Janice M Fullerton… in BMC Psychiatry (2012)

Article

Developmental trajectory of the endocannabinoid system in human dorsolateral prefrontal cortex

Endocannabinoids provide control over cortical neurotransmission. We investigated the developmental expression of key genes in the endocannabinoid system across human postnatal life and determined whether they...

Leonora E Long, Jonna Lind, Maree Webster, Cynthia Shannon Weickert in BMC Neuroscience (2012)

Article

Testosterone regulation of sex steroid-related mRNAs and dopamine-related mRNAs in adolescent male rat substantia nigra

Increased risk of schizophrenia in adolescent males indicates that a link between the development of dopamine-related psychopathology and testosterone-driven brain changes may exist. However, contradictions as...

Tertia D Purves-Tyson, David J Handelsman, Kay L Double… in BMC Neuroscience (2012)

Article

Neuroplasticity in Depressed Individuals Compared with Healthy Controls

Several lines of evidence suggest that neuroplasticity is impaired in depression. This study aimed to compare neuroplasticity in 23 subjects with DSM-IV major depressive episode and 23 age- and gender-matched ...

Michael J Player, Janet L Taylor, Cynthia Shannon Weickert… in Neuropsychopharmacology (2013)

Article

Dysregulation of glucocorticoid receptor co-factors FKBP5, BAG1 and PTGES3 in prefrontal cortex in psychotic illness

Molecular abnormalities within the glucocorticoid receptor (GR) stress signaling pathway may confer, or reflect, susceptibility to stress in schizophrenia and bipolar disorder, but the extent of such abnormali...

Duncan Sinclair, Stu G. Fillman, Maree J. Webster… in Scientific Reports (2013)

Article

Impacts of stress and sex hormones on dopamine neurotransmission in the adolescent brain

Adolescence is a developmental period of complex neurobiological change and heightened vulnerability to psychiatric illness. As a result, understanding factors such as sex and stress hormones which drive brain...

Duncan Sinclair, Tertia D Purves-Tyson, Katherine M Allen… in Psychopharmacology (2014)

Article

The effect of adolescent testosterone on hippocampal BDNF and TrkB mRNA expression: relationship with cell proliferation

Testosterone attenuates postnatal hippocampal neurogenesis in adolescent male rhesus macaques through altering neuronal survival. While brain-derived neurotropic factor (BDNF)/ tyrosine kinase receptor B (TrkB...

Katherine M Allen, Tertia D Purves-Tyson, Samantha J Fung… in BMC Neuroscience (2015)

Article

Relationship between somatostatin and death receptor expression in the orbital frontal cortex in schizophrenia: a postmortem brain mRNA study

Recently, we provided evidence showing reductions in GAD67 and Dlx mRNAs in the orbital frontal cortex (OFC) in schizophrenia. It is unknown whether these reductions relate mainly to somatostatin (SST) or parv...

Dipesh Joshi, Vibeke S Catts, Juan C Olaya, Cynthia Shannon Weickert in npj Schizophrenia (2015)

Article

Selective Estrogen Receptor Modulation Increases Hippocampal Activity during Probabilistic Association Learning in Schizophrenia

People with schizophrenia show probabilistic association learning impairment in conjunction with abnormal neural activity. The selective estrogen receptor modulator (SERM) raloxifene preserves neural activity ...

Jochen Kindler, Cynthia Shannon Weickert, Ashley J Skilleter… in Neuropsychopharmacology (2015)

Article

Postsynaptic density levels of the NMDA receptor NR1 subunit and PSD-95 protein in prefrontal cortex from people with schizophrenia

There is converging evidence of involvement of N-methyl-d-aspartate (NMDA) receptor hypofunction in the pathophysiology of schizophrenia. Our group recently identified a decrease in total NR1 mRNA and protein exp...

Vibeke Sørensen Catts, Dominique Suzanne Derminio, Chang-Gyu Hahn… in npj Schizophrenia (2015)

Article

The impact of premorbid and current intellect in schizophrenia: cognitive, symptom, and functional outcomes

Cognitive heterogeneity among people with schizophrenia has been defined on the basis of premorbid and current intelligence quotient (IQ) estimates. In a relatively large, community cohort, we aimed to indepen...

Ruth Wells, Vaidy Swaminathan, Suresh Sundram, Danielle Weinberg… in npj Schizophrenia (2015)

Article

Hormone modulation improves cognition in schizophrenia

Cynthia Shannon Weickert, Thomas W Weickert in Neuropsychopharmacology (2016)

Article

Using blood cytokine measures to define high inflammatory biotype of schizophrenia and schizoaffective disorder

Increases in pro-inflammatory cytokines are found in the brain and blood of people with schizophrenia. However, increased cytokines are not evident in all people with schizophrenia, but are found in a subset. ...

Danny Boerrigter, Thomas W. Weickert, Rhoshel Lenroot… in Journal of Neuroinflammation (2017)