51 Result(s)
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Cynthia Shannon Weickert
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Open AccessRNA-sequencing suggests extracellular matrix and vasculature dysregulation could impair neurogenesis in schizophrenia cases with elevated inflammation
A subgroup of schizophrenia cases with elevated inflammation have reduced neurogenesis markers and increased macrophage density in the human subependymal zone (SEZ; also termed subventricular zone or SVZ) neur...
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Open AccessSex- and suicide-specific alterations in the kynurenine pathway in the anterior cingulate cortex in major depression
Major depressive disorder (MDD) is a serious psychiatric disorder that in extreme cases can lead to suicide. Evidence suggests that alterations in the kynurenine pathway (KP) contribute to the pathology of MDD...
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Open AccessCorrection: Obesity and brain structure in schizophrenia – ENIGMA study in 3021 individuals
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A path to novel, effective treatments for schizophrenia
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Cytomegalovirus antibodies are associated with mood disorders, suicide, markers of neuroinflammation, and microglia activation in postmortem brain samples
Cytomegalovirus (CMV) is a common, neurotrophic herpesvirus that can be reactivated by inflammation and cause central nervous system disease. We hypothesize that CMV may contribute to the neuroinflammation tha...
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Open AccessPerturbed iron biology in the prefrontal cortex of people with schizophrenia
Despite loss of grey matter volume and emergence of distinct cognitive deficits in young adults diagnosed with schizophrenia, current treatments for schizophrenia do not target disruptions in late maturational...
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Open AccessSingle-nucleus RNA sequencing of midbrain blood-brain barrier cells in schizophrenia reveals subtle transcriptional changes with overall preservation of cellular proportions and phenotypes
The midbrain is an extensively studied brain region in schizophrenia, in view of its reported dopamine pathophysiology and neuroimmune changes associated with this disease. Besides the dopaminergic system, the...
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Open AccessCorrection: Obesity and brain structure in schizophrenia – ENIGMA study in 3021 individuals
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Open AccessObesity and brain structure in schizophrenia – ENIGMA study in 3021 individuals
Schizophrenia is frequently associated with obesity, which is linked with neurostructural alterations. Yet, we do not understand how the brain correlates of obesity map onto the brain changes in schizophrenia....
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Open AccessCell type-specific manifestations of cortical thickness heterogeneity in schizophrenia
Brain morphology differs markedly between individuals with schizophrenia, but the cellular and genetic basis of this heterogeneity is poorly understood. Here, we sought to determine whether cortical thickness ...
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Open AccessPeripheral NF-κB dysregulation in people with schizophrenia drives inflammation: putative anti-inflammatory functions of NF-κB kinases
Elevations in plasma levels of pro-inflammatory cytokines and C-reactive protein (CRP) in patient blood have been associated with impairments in cognitive abilities and more severe psychiatric symptoms in peop...
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Open AccessIdentifying gene expression profiles associated with neurogenesis and inflammation in the human subependymal zone from development through aging
The generation of new neurons within the mammalian forebrain continues throughout life within two main neurogenic niches, the subgranular zone (SGZ) of the hippocampal dentate gyrus, and the subependymal zone ...
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Open AccessA schizophrenia subgroup with elevated inflammation displays reduced microglia, increased peripheral immune cell and altered neurogenesis marker gene expression in the subependymal zone
Inflammation regulates neurogenesis, and the brains of patients with schizophrenia and bipolar disorder have reduced expression of neurogenesis markers in the subependymal zone (SEZ), the birthplace of inhibit...
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A new suspect in the unsolved case of neuroinflammation in schizophrenia
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Reduced adult neurogenesis is associated with increased macrophages in the subependymal zone in schizophrenia
Neural stem cells in the human subependymal zone (SEZ) generate neuronal progenitor cells that can differentiate and integrate as inhibitory interneurons into cortical and subcortical brain regions; yet the ex...
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Open AccessNeuroinflammation in schizophrenia: the role of nuclear factor kappa B
Neuroinflammation, particularly in the dorsolateral prefrontal cortex, is well-established in a subset of people with schizophrenia, with significant increases in inflammatory markers including several cytokin...
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Open AccessReductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia
Reductions in the GABAergic neurotransmitter system exist across multiple brain regions in schizophrenia and encompass both pre- and postsynaptic components. While reduced midbrain GABAergic inhibitory neurotr...
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Increased peripheral inflammation in schizophrenia is associated with worse cognitive performance and related cortical thickness reductions
While the biological substrates of brain and behavioural changes in persons with schizophrenia remain unclear, increasing evidence implicates that inflammation is involved. In schizophrenia, including first-ep...
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Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 6...
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Open AccessIncreased levels of midbrain immune-related transcripts in schizophrenia and in murine offspring after maternal immune activation
The pathophysiology of dopamine dysregulation in schizophrenia involves alterations at the ventral midbrain level. Given that inflammatory mediators such as cytokines influence the functional properties of mid...
