33 Result(s)

Article

Catechol O-Methyltransferase (COMT) mRNA Expression in the Dorsolateral Prefrontal Cortex of Patients with Schizophrenia

Human prefrontal cortical neurons express catechol O-methyltransferase (COMT), an enzyme that inactivates the neurotransmitter dopamine. A functional polymorphism of COMT, Val^108/158 Met, affects prefrontal funct...

Mitsuyuki Matsumoto, Cynthia Shannon Weickert, Senda Beltaifa… in Neuropsychopharmacology (2003)

Article

Glutamate Carboxypeptidase II Gene Expression in the Human Frontal and Temporal Lobe in Schizophrenia

There is decreased activity of glutamate carboxypeptidase II (GCP II) in the dorsolateral prefrontal cortex (DLPFC) and hippocampus of patients with schizophrenia. GCP II hydrolzses N-acetyl-α L-aspartyl-L-glutam...

Subroto Ghose, Cynthia Shannon Weickert, Sarah M Colvin… in Neuropsychopharmacology (2004)

Article

Effects of Chronic Haloperidol and Clozapine Treatment on Neurogenesis in the Adult Rat Hippocampus

It has been proposed that the therapeutic benefits of treatment with antidepressants and mood stabilizers may arise partially from their ability to stimulate neurogenesis. This study was designed to examine th...

Nader D Halim, Cynthia Shannon Weickert, Benjamin W McClintock… in Neuropsychopharmacology (2004)

Article

Abnormal Glucocorticoid Receptor mRNA and Protein Isoform Expression in the Prefrontal Cortex in Psychiatric Illness

Stress has been implicated in the onset and illness course of schizophrenia and bipolar disorder. The effects of stress in these disorders may be mediated by abnormalities of the hypothalamic–pituitary–adrenal...

Duncan Sinclair, Shan Yuan Tsai, Heng Giap Woon… in Neuropsychopharmacology (2011)

Article

Neuroplasticity in Depressed Individuals Compared with Healthy Controls

Several lines of evidence suggest that neuroplasticity is impaired in depression. This study aimed to compare neuroplasticity in 23 subjects with DSM-IV major depressive episode and 23 age- and gender-matched ...

Michael J Player, Janet L Taylor, Cynthia Shannon Weickert… in Neuropsychopharmacology (2013)

Article

Relationship between somatostatin and death receptor expression in the orbital frontal cortex in schizophrenia: a postmortem brain mRNA study

Recently, we provided evidence showing reductions in GAD67 and Dlx mRNAs in the orbital frontal cortex (OFC) in schizophrenia. It is unknown whether these reductions relate mainly to somatostatin (SST) or parv...

Dipesh Joshi, Vibeke S Catts, Juan C Olaya, Cynthia Shannon Weickert in npj Schizophrenia (2015)

Article

Selective Estrogen Receptor Modulation Increases Hippocampal Activity during Probabilistic Association Learning in Schizophrenia

People with schizophrenia show probabilistic association learning impairment in conjunction with abnormal neural activity. The selective estrogen receptor modulator (SERM) raloxifene preserves neural activity ...

Jochen Kindler, Cynthia Shannon Weickert, Ashley J Skilleter… in Neuropsychopharmacology (2015)

Article

Postsynaptic density levels of the NMDA receptor NR1 subunit and PSD-95 protein in prefrontal cortex from people with schizophrenia

There is converging evidence of involvement of N-methyl-d-aspartate (NMDA) receptor hypofunction in the pathophysiology of schizophrenia. Our group recently identified a decrease in total NR1 mRNA and protein exp...

Vibeke Sørensen Catts, Dominique Suzanne Derminio, Chang-Gyu Hahn… in npj Schizophrenia (2015)

Article

The impact of premorbid and current intellect in schizophrenia: cognitive, symptom, and functional outcomes

Cognitive heterogeneity among people with schizophrenia has been defined on the basis of premorbid and current intelligence quotient (IQ) estimates. In a relatively large, community cohort, we aimed to indepen...

Ruth Wells, Vaidy Swaminathan, Suresh Sundram, Danielle Weinberg… in npj Schizophrenia (2015)

Article

Hormone modulation improves cognition in schizophrenia

Cynthia Shannon Weickert, Thomas W Weickert in Neuropsychopharmacology (2016)

Article

Elevated peripheral expression of neuregulin-1 (NRG1) mRNA isoforms in clozapine-treated schizophrenia patients

Differential expression of neuregulin-1 (NRG1) mRNA isoforms and proteins has been reported in schizophrenia, primarily in post-mortem brain tissue. In this study, we examined 12 NRG1 SNPs, eight NRG1 mRNA isofor...

Md Shaki Mostaid, Ting Ting Lee, Gursharan Chana… in Translational Psychiatry (2017)

Article

Decreased Brain pH as a Shared Endophenotype of Psychiatric Disorders

Although the brains of patients with schizophrenia and bipolar disorder exhibit decreased brain pH relative to those of healthy controls upon postmortem examination, it remains controversial whether this findi...

Hideo Hagihara, Vibeke S Catts, Yuta Katayama, Hirotaka Shoji… in Neuropsychopharmacology (2018)

Article

Temporal proteomic profiling of postnatal human cortical development

Healthy cortical development depends on precise regulation of transcription and translation. However, the dynamics of how proteins are expressed, function and interact across postnatal human cortical developme...

Michael S. Breen, Sureyya Ozcan, Jordan M. Ramsey, Zichen Wang… in Translational Psychiatry (2018)

Article

White matter neuron biology and neuropathology in schizophrenia

Schizophrenia is considered a neurodevelopmental disorder as it often manifests before full brain maturation and is also a cerebral cortical disorder where deficits in GABAergic interneurons are prominent. Whi...

Ryan J. Duchatel, Cynthia Shannon Weickert, Paul A. Tooney in npj Schizophrenia (2019)

Article

Increased macrophages and changed brain endothelial cell gene expression in the frontal cortex of people with schizophrenia displaying inflammation

Elevated pro-inflammatory cytokines exist in both blood and brain of people with schizophrenia but how this affects molecular indices of the blood–brain barrier (BBB) is unclear. Eight mRNAs relating to BBB fu...

Helen Q. Cai, Vibeke S. Catts, Maree J. Webster, Cherrie Galletly… in Molecular Psychiatry (2020)

Article

Dysregulation of kynurenine metabolism is related to proinflammatory cytokines, attention, and prefrontal cortex volume in schizophrenia

The kynurenine pathway (KP) of tryptophan (TRP) catabolism links immune system activation with neurotransmitter signaling. The KP metabolite kynurenic acid (KYNA) is increased in the brains of people with schi...

Jochen Kindler, Chai K. Lim, Cynthia Shannon Weickert… in Molecular Psychiatry (2020)

Article

Increased levels of midbrain immune-related transcripts in schizophrenia and in murine offspring after maternal immune activation

The pathophysiology of dopamine dysregulation in schizophrenia involves alterations at the ventral midbrain level. Given that inflammatory mediators such as cytokines influence the functional properties of mid...

Tertia D. Purves-Tyson, Ulrike Weber-Stadlbauer, Juliet Richetto… in Molecular Psychiatry (2021)

Article

Neuroinflammation in schizophrenia: the role of nuclear factor kappa B

Neuroinflammation, particularly in the dorsolateral prefrontal cortex, is well-established in a subset of people with schizophrenia, with significant increases in inflammatory markers including several cytokin...

Caitlin E. Murphy, Adam K. Walker, Cynthia Shannon Weickert in Translational Psychiatry (2021)