73 Result(s)

Article

Diastereoselective dearomatization of indoles via photocatalytic hydroboration on hydramine-functionalized carbon nitride

A protocol for trans-hydroboration of indole derivatives using heterogeneous photocatalysis with NHC-borane has been developed, addressing a persistent challenge in organic synthesis. The protocol, leveraging hig...

Qiao Zhang, Wengang Xu, Qiong Liu, Congjian **a, Qi Shao… in Nature Communications (2024)

Article

PRDM14 extinction enables the initiation of trophoblast stem cell formation

Trophoblast stem cells (TSCs) can be chemically converted from embryonic stem cells (ESCs) in vitro. Although several transcription factors (TFs) have been recognized as essential for TSC formation, it remains...

Chunfang Xu, Weijie Zhao, Li** Peng, Tingxuan Yin… in Cellular and Molecular Life Sciences (2024)

Article

Correction to: Dominant‑negative transforming growth factor‑β receptor‑armoured mesothelin‑targeted chimeric antigen receptor T cells slow tumour growth in a mouse model of ovarian cancer

Ke Li, **g Xu, **g Wang, Chong Lu, Yilin Dai… in Cancer Immunology, Immunotherapy (2024)

Article

Bowel wall thickness measured by MRI is useful for early diagnosis of bowel endometriosis

To evaluate MRI features of bowel endometriosis (BE) and verify its clinical significance compared with pathological diagnosis.

Yunxi Zheng, Shouxin Gu, **gyao Ruan, **aofang Yi, Congjian Xu in European Radiology (2023)

Article

Establishment and characterization of a novel cell line (SCCOHT-CH-1) and PDX models derived from Chinese patients of small cell ovarian carcinoma of the hypercalcemic type

Small cell carcinoma of the ovary hypercalcemic type (SCCOHT) is a rare and aggressive malignancy that poses a significant clinical challenge due to its grim prognosis. Unfortunately, only three SCCOHT cell li...

Yi Gao, Kewei Zheng, Mingyi Kang, **g Xu, Yan Ning, Weiguo Hu, Ke Li… in Human Cell (2023)

Article

The molecular regulatory mechanisms of meiotic arrest and resumption in Oocyte development and maturation

In human female primordial germ cells, the transition from mitosis to meiosis begins from the fetal stage. In germ cells, meiosis is arrested at the diplotene stage of prophase in meiosis I (MI) after synapsis...

Zhenle Pei, Ke Deng, Congjian Xu, Shuo Zhang in Reproductive Biology and Endocrinology (2023)

Article

Contribution of HIF-1α/BNIP3-mediated autophagy to lipid accumulation during irinotecan-induced liver injury

Irinotecan is a topoisomerase I inhibitor which has been widely used to combat several solid tumors, whereas irinotecan therapy can induce liver injury. Liver injury generally leads to tissue hypoxia, and hypo...

Congjian Shi, Zhenghong Zhang, Renfeng Xu, Yan Zhang, Zhengchao Wang in Scientific Reports (2023)

Article

Dominant-negative transforming growth factor-β receptor-armoured mesothelin-targeted chimeric antigen receptor T cells slow tumour growth in a mouse model of ovarian cancer

Ovarian cancer is a major cause of death among all gynaecological cancers. Although surgery, chemotherapy and targeted therapy have yielded successful outcomes, the 5-year survival rate remains < 30%. Adoptive...

Ke Li, **g Xu, **g Wang, Chong Lu, Yilin Dai… in Cancer Immunology, Immunotherapy (2023)

Article

Preoperative and intraoperative assessment of myometrial invasion in patients with FIGO stage I non-endometrioid endometrial carcinoma—a large-scale, multi-center, and retrospective study

Myometrial invasion is a prognostic factor for lymph node metastases and decreased survival in non-endometrioid endometrial carcinoma patients. Herein, we explored the mode of myometrial invasion diagnosis in ...

**aohang Yang, **g**g Yin, Yu Fu, Yuanming Shen, Chuyao Zhang… in Diagnostic Pathology (2023)

Article

Evaluation of serum CA125-Tn glycoform in peritoneal dissemination and surgical completeness of high-grade serous ovarian cancer

Peritoneal dissemination is the predominant feature of malignant progression in ovarian cancer and is a major cause of poor surgical outcomes and clinical prognoses. Abnormal glycosylation of carbohydrate anti...

**ayu **, Ming Du, Yisheng Wang, Yuefei Wang, Yingying Lu… in Journal of Ovarian Research (2022)

Article

Brain milieu induces early microglial maturation through the BAX-Notch axis

Microglia are derived from primitive myeloid cells and gain their early identity in the embryonic brains. However, the mechanism by which the brain milieu confers microglial maturation signature remains elusiv...

Fangying Zhao, Jiangyong He, Jun Tang, Nianfei Cui, Yanyan Shi… in Nature Communications (2022)

Article

Genetic deconvolution of fetal and maternal cell-free DNA in maternal plasma enables next-generation non-invasive prenatal screening

Current non-invasive prenatal screening (NIPS) analyzes circulating fetal cell-free DNA (cfDNA) in maternal peripheral blood for selected aneuploidies or microdeletion/duplication syndromes. Many genetic disor...

Chenming Xu, Jianli Li, Songchang Chen, **aoqiang Cai, Ruilin **g… in Cell Discovery (2022)

Article

Retro-inversion follicle-stimulating hormone peptide-modified nanoparticles for delivery of PDK2 shRNA against chemoresistant ovarian cancer by switching glycolysis to oxidative phosphorylation

Most ovarian cancers are diagnosed at advanced stages characterized by abdominal dissemination and frequently exhibit chemoresistance. Pyruvate dehydrogenase kinase 2 (PDK2) regulates the switch between glycol...

Meng Zhang, Ming Du, **ngling Qi, Yumeng Wang, Guiling Li… in Cancer Nanotechnology (2022)

Article

An effective AKT inhibitor-PARP inhibitor combination therapy for recurrent ovarian cancer

Although the use of PARP inhibitor has received considerable amount of attention in ovarian cancer, PARP inhibitor resistance still emerges with disease progression. PI3K/AKT pathway inhibitors have been propo...

**g Xu, Yi Gao, **aotian Luan, Ke Li, **g Wang… in Cancer Chemotherapy and Pharmacology (2022)