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Article
Role of sodium-glucose cotransporter-2 inhibitors in risk of chronic kidney disease among patients with type 2 diabetes mellitus
This retrospective analysis aims to explore the risk of chronic kidney disease (CKD) among type 2 diabetes mellitus (DM) patients with different scores of adapted diabetes complications severity index (DCSI) w...
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Article
Open AccessLong-term ambient hydrocarbon exposure and incidence of urinary bladder cancer
Particulate matter and volatile organic compounds, including total hydrocarbons (THCs), are major ambient air pollutants. Primary nonmethane hydrocarbons (NMHCs) originate from vehicle emissions. The associati...
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Article
Early Hyperchloremia is Independently Associated with Death or Disability in Patients with Intracerebral Hemorrhage
On the basis of increased mortality associated with hyperchloremia among critically ill patients, we investigated the effect of occurrence of early hyperchloremia on death or disability at 90 days in patients ...
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Article
Open AccessEffects of colchicine use on ischemic and hemorrhagic stroke risk in diabetic patients with and without gout
This study aimed to determine the effect of colchicine use on the risk of stroke among patients with diabetes mellitus (DM). We retrospectively enrolled patients with DM between 2000 and 2013 from the Longitud...
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Article
Open AccessA cohort study evaluating the risk of stroke associated with long-term exposure to ambient fine particulate matter in Taiwan
Evidences have shown that the stroke risk associated with long-term exposure to particulate matter with an aerodynamic diameter of ≤2.5 μm (PM2.5) varies among people in North America, Europe and Asia, but studie...
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Article
Open AccessHerpes zoster in patients with sciatica
Several diseases are associated with herpes zoster (HZ). However, whether sciatica is a stressor leading to HZ development remains unclear. Here, we evaluated the occurrence of HZ in patients with sciatica.
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Article
Risk of obstructive sleep apnea in patients with schizophrenia: a nationwide population-based cohort study
Patients with schizophrenia (SCZ) have a higher prevalence of known risk factors for obstructive sleep apnea (OSA). This study aims to determine if SCZ patients are at increased risk of incident OSA.
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Article
Risk of systemic lupus erythematosus in patients with endometriosis: A nationwide population-based cohort study
The etiology of endometriosis is mostly under-explored, but abnormalities in the immune system leading to an autoimmune reaction have been suggested. The systemic lupus erythematosus (SLE) is one of the most c...
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Article
A Population-Based Cohort Study Examining the Long-term Risk of Repeated Surgery in Non-Helicobacter pylori-Infected PPU Patients Who Underwent Simple Closure
The management of perforated peptic ulcer (PPU) has shifted from vagotomy/drainage to simple closure, followed by postoperative proton pump inhibitors (PPIs) and Helicobacter pylori (HP) eradication. Few studies ...
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Article
Open AccessIncreased risk of knee osteoarthritis in patients using oral N-acetylcysteine: a nationwide cohort study
Knee osteoarthritis (OA) is known to be a progressive degenerative disorder; however, recent evidence suggests that inflammatory mediators contribute to cartilage degradation. Studies have reported that N-acet...
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Article
Open AccessA cohort study: The Association Between Autoimmune Disorders and Leptospirosis
There are limited studies on the association between systemic autoimmune rheumatic diseases (SARDs) and leptospirosis. Therefore, this study aims to identify the effects of leptospirosis on the risks of develo...
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Article
Open AccessLegal and ethical framework for global health information and biospecimen exchange - an international perspective
The progress of electronic health technologies and biobanks holds enormous promise for efficient research. Evidence shows that studies based on sharing and secondary use of data/samples have the potential to s...
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Article
Open AccessAspirin decreases hepatocellular carcinoma risk in hepatitis C virus carriers: a nationwide cohort study
Aspirin has been found to lower the occurrence rates of some cancers through the inhibition of the cyclooxygenase enzyme. For example, there is a well-known association between aspirin use and the occurrence o...
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Article
Systemic autoimmune diseases are associated with an increased risk of obsessive–compulsive disorder: a nationwide population-based cohort study
Studies suggested autoimmunity plays a role in the etiology of obsessive–compulsive disorder (OCD). The purpose of this study was to determine if a history of systemic autoimmune diseases (SADs) is associated ...
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Article
Open AccessAssessing whether the association between rheumatoid arthritis and schizophrenia is bidirectional: A nationwide population-based cohort study
Since many studies have shown a reduction in the incidence of rheumatoid arthritis (RA) in patients with schizophrenia (SCZ), little effort has been devoted to studying this link in the Asian population. Moreo...
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Article
Risk of gallstones in patients with obstructive sleep apnea: a nationwide observational cohort study
To assess the association between obstructive sleep apnea (OSA) and gallstones.
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Article
Open AccessAcupuncture decreased the risk of coronary heart disease in patients with rheumatoid arthritis in Taiwan: a Nationwide propensity score-matched study
Patients with rheumatoid arthritis (RA) have a higher risk of coronary heart disease (CHD). Acupuncture, a commonly used treatment for patients with RA, has not been reported to prevent CHD in patients with RA...
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Article
Open AccessCerebral Motor Functional Connectivity at the Acute Stage: An Outcome Predictor of Ischemic Stroke
Sixty-seven patients with first acute ischemic stroke onset between 3 to 7 days and 25 age- and sex- matched controls were analyzed for the performance of a resting-state functional MRI to investigate whether ...
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Article
Women who had appendectomy have increased risk of systemic lupus erythematosus: a nationwide cohort study
The appendix is involved in immune function, and an appendectomy may alter the immune system. Studies evaluating the relationship between previous appendectomy and the risk of systemic lupus erythematosus (SLE...
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Article
Open AccessRisk of Hyperlipidemia in Women with Hysterectomy-A Retrospective Cohort Study in Taiwan
Hysterectomy has been associated with metabolic change and cardiovascular risk for women after removing the uterus, but inconclusive. This large retrospective cohort study evaluated the hyperlipidemia risk for...
