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Article
New ursolic acid derivatives bearing 1,2,3-triazole moieties: design, synthesis and anti-inflammatory activity in vitro and in vivo
In order to discover novel anti-inflammatory agents, three series of compounds obtained by appending 1,2,3-triazole moieties on ursolic acid were designed and synthesized. All compounds have been screened for ...
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Article
Synthesis and evaluation of ursolic acid-based 1,2,4-triazolo[1,5-a]pyrimidines derivatives as anti-inflammatory agents
Here, two series of novel ursolic acid-based 1,2,4-triazolo[1,5-a]pyrimidines derivatives were synthesized and screened for their anti-inflammatory activity by evaluating their inhibition effect of using LPS-i...
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Article
Design, synthesis and evaluation of dihydrotriazine derivatives-bearing 5-aryloxypyrazole moieties as antibacterial agents
In the present investigation, a series of dihydrotriazine derivatives-bearing 5-aryloxypyrazole moieties were synthesized and their structures were confirmed by different spectral tools. The biological evaluat...
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Article
Synthesis and molecular docking studies of novel pyrimidine derivatives as potential antibacterial agents
The present work describes the in vitro antibacterial evaluation of some new pyrimidine derivatives. Twenty-two target compounds were designed, synthesized and preliminarily explored for their antimicrobial ac...
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Article
Open AccessAssociation of FOXJ1 polymorphisms with systemic lupus erythematosus and rheumatoid arthritis in Korean population
The forkhead-box J1 (FOXJ1) transcription factor could suppress a spontaneous activation of T cells and B cells through an induction of IκBβ that results in repression of NF-κB activity. In Foxj1 deficiency mi...
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Article
Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population
Interleukin 27 (IL-27) acts as a versatile cytokine in the early regulation of Th1 initiation and in the negative regulation of the Th2 factor GATA-3. IL-27, which was discovered as a novel heterodimeric cytok...
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Article
Open AccessAnalysis of the variations in IL-28RA gene and their association with allergic rhinitis
IL-28RA is one of the important candidate genes for complex trait of genetic diseases, but there is no published information of the genetic variation in this gene. We scanned the seven exons and their boundary...
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Article
Identification of single nucleotide polymorphisms in FOXJ1 and their association with allergic rhinitis
Forkhead-box J1 (FOXJ1) is a presumed transcription factor that can suppress T cell activity, at least partially, through the repression of NFκB activity. Thus, dysregulation of FOXJ1 is thought to be associated ...
