8 Result(s)
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Article
Open AccessCorrection to: Incidence, clinical features, and outcomes of COVID-19 in Canada: Impact of sex and age
An amendment to this paper has been published and can be accessed via the original article.
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Article
Open AccessIncidence, clinical features, and outcomes of COVID-19 in Canada: impact of sex and age
Male sex and older age have been reported to be associated with worse outcomes from COVID-19. It was postulated that estrogens may play a role in reducing the severity of the disease and may therefore offer a ...
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Article
Open AccessWnt/β-catenin signalling in ovarian cancer: Insights into its hyperactivation and function in tumorigenesis
Epithelial ovarian cancer (EOC) is the deadliest female malignancy. The Wnt/β-catenin pathway plays critical roles in regulating embryonic development and physiological processes. This pathway is tightly regul...
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A circular RNA circ-DNMT1 enhances breast cancer progression by activating autophagy
Circular RNAs are a large group of noncoding RNAs that are widely expressed in mammalian cells. Genome-wide analyses have revealed abundant and evolutionarily conserved circular RNAs across species, which sugg...
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Article
Reduced expression of activin receptor-like kinase 7 in breast cancer is associated with tumor progression
To explore the clinical implication of activin receptor-like kinase 7 (ALK7) expression in breast cancer, we evaluated its protein level in six kinds of human breast tissue samples, including adjacent normal t...
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Open AccessTransforming growth factor-beta inhibits aromatase gene transcription in human trophoblast cells via the Smad2 signaling pathway
Transforming growth factor-beta (TGF-beta) is known to exert multiple regulatory functions in the human placenta, including inhibition of estrodial production. We have previously reported that TGF-beta1 decrea...
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Open AccessPotential targets of transforming growth factor-beta1 during inhibition of oocyte maturation in zebrafish
TGF-beta is a multifunctional growth factor involved in regulating a variety of cellular activities. Unlike mammals, the function of TGF-beta in the reproduction of lower vertebrates, such as fish, is not clea...
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Open AccessActivin-A up-regulates type I activin receptor mRNA levels in human immortalized extravillous trophoblast cells.
Activin is known to play an important regulatory role in reproduction, including pregnancy. To further examine the role and signaling mechanism of activin in regulating placental function, the steady-state lev...
