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Article
Integration of text-mining and telemedicine appointment optimization
Nowadays, many countries view profitable telemedicine as a viable strategy for meeting healthcare needs, especially during the pandemic. Existing appointment models are based on patients’ structured data. We s...
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Article
Open AccessCorrection to: The circular RNA hsa_circ_0001394 promotes hepatocellular carcinoma progression by targeting the miR-527/UBE2A axis
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Article
Open AccessThe circular RNA hsa_circ_0001394 promotes hepatocellular carcinoma progression by targeting the miR-527/UBE2A axis
Circular RNAs (circRNAs) have been recognized as significant participants in the progression of different cancers; however, the detailed mechanisms of circRNAs in hepatocellular carcinoma (HCC) remain unclear....
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Chapter and Conference Paper
Two-Stage Chance-Constrained Telemedicine Assignment Model with No-Show Behavior and Uncertain Service Duration
The current global pandemic of COVID-19 has caused significant strain on the medical resources of the healthcare providers, so more and more hospitals use telemedicine and virtual care for remote treatment (i....
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Article
Open AccessCorrection to: Incidence, clinical features, and outcomes of COVID-19 in Canada: Impact of sex and age
An amendment to this paper has been published and can be accessed via the original article.
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Article
Open AccessIncidence, clinical features, and outcomes of COVID-19 in Canada: impact of sex and age
Male sex and older age have been reported to be associated with worse outcomes from COVID-19. It was postulated that estrogens may play a role in reducing the severity of the disease and may therefore offer a ...
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Article
Open AccessWnt/β-catenin signalling in ovarian cancer: Insights into its hyperactivation and function in tumorigenesis
Epithelial ovarian cancer (EOC) is the deadliest female malignancy. The Wnt/β-catenin pathway plays critical roles in regulating embryonic development and physiological processes. This pathway is tightly regul...
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Article
Open AccessEnhanced breast cancer progression by mutant p53 is inhibited by the circular RNA circ-Ccnb1
TP53 mutations occur in many different types of cancers that produce mutant p53 proteins. The mutant p53 proteins have lost wild-type p53 activity and gained new functions that contribute to malignant tumor pr...
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Article
A circular RNA circ-DNMT1 enhances breast cancer progression by activating autophagy
Circular RNAs are a large group of noncoding RNAs that are widely expressed in mammalian cells. Genome-wide analyses have revealed abundant and evolutionarily conserved circular RNAs across species, which sugg...
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Article
Open AccessActivated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia
Miscarriage and intrauterine growth restriction (IUGR) are devastating complications in fetal/neonatal alloimmune thrombocytopenia (FNAIT). We previously reported the mechanisms for bleeding diatheses, but it ...
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Article
Monitoring Toxic Ionic Liquids in Zebrafish (Danio rerio) with Desorption Electrospray Ionization Mass Spectrometry Imaging (DESI-MSI)
Ambient mass spectrometry imaging has become an increasingly powerful technique for the direct analysis of biological tissues in the open environment with minimal sample preparation and fast analysis times. In...
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Article
Dicer1/miR-29/HMGCR axis contributes to hepatic free cholesterol accumulation in mouse non-alcoholic steatohepatitis
Dicer1 is an enzyme essential for microRNA (miRNA) maturation. The loss of miRNAs resulted from Dicer1 deficiency greatly contributes to the progression of many diseases, including lipid dysregulation, but its ro...
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Article
1,2:5,6-dianhydrogalactitol inhibits human glioma cell growth in vivo and in vitro by arresting the cell cycle at G2/M phase
1,2:5,6-dianhydrogalactitol (DAG) is a hexitol epoxide with marked antitumor activity against multiple types of cancer cells, but the molecular mechanisms by which DAG functions as an antitumor agent is largel...
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Article
MicroRNA-1304 suppresses human non-small cell lung cancer cell growth in vitro by targeting heme oxygenase-1
Previous studies have shown that microRNA-1304 (miR-1304) is dysregulated in certain types of cancers, including non-small cell lung cancer (NSCLC), and might be involved in tumor survival and/or growth. In th...
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Article
Open AccessHypoxia-inducible miR-210 contributes to preeclampsia via targeting thrombospondin type I domain containing 7A
Preeclampsia, a relatively common pregnancy disorder, is a major contributor to maternal mortality and morbidity worldwide. An elevation in microRNA-210 (miR-210) expression in the placenta has been reported t...
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Article
Chinese rural land expropriation law: problems, prescriptions and obstacles
Extensive rural land expropriation has been a source of social deprivation and contention in contemporary China. This article provides a comprehensive state-of-art analysis of the Chinese law of rural land exp...
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Article
Reduced expression of activin receptor-like kinase 7 in breast cancer is associated with tumor progression
To explore the clinical implication of activin receptor-like kinase 7 (ALK7) expression in breast cancer, we evaluated its protein level in six kinds of human breast tissue samples, including adjacent normal t...
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Article
Open AccessTransforming growth factor-beta inhibits aromatase gene transcription in human trophoblast cells via the Smad2 signaling pathway
Transforming growth factor-beta (TGF-beta) is known to exert multiple regulatory functions in the human placenta, including inhibition of estrodial production. We have previously reported that TGF-beta1 decrea...
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Article
Open AccessPotential targets of transforming growth factor-beta1 during inhibition of oocyte maturation in zebrafish
TGF-beta is a multifunctional growth factor involved in regulating a variety of cellular activities. Unlike mammals, the function of TGF-beta in the reproduction of lower vertebrates, such as fish, is not clea...
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Article
Open AccessActivin-A up-regulates type I activin receptor mRNA levels in human immortalized extravillous trophoblast cells.
Activin is known to play an important regulatory role in reproduction, including pregnancy. To further examine the role and signaling mechanism of activin in regulating placental function, the steady-state lev...
