14 Result(s)
within
Christopher D. Scharer
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Article
Open AccessDistinct transcriptomes and autocrine cytokines underpin maturation and survival of antibody-secreting cells in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple autoantibody types, some of which are produced by long-lived plasma cells (LLPC). Active SLE generates increased circulatin...
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Prevention of respiratory virus transmission by resident memory CD8+ T cells
An ideal vaccine both attenuates virus growth and disease in infected individuals and reduces the spread of infections in the population, thereby generating herd immunity. Although this strategy has proved suc...
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Open AccessDistinct transcriptomic and epigenomic modalities underpin human memory T cell subsets and their activation potential
Human memory T cells (MTC) are poised to rapidly respond to antigen re-exposure. Here, we derived the transcriptional and epigenetic programs of resting and ex vivo activated, circulating CD4+ and CD8+ MTC subset...
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PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program
Combination therapy with PD-1 blockade and IL-2 is highly effective during chronic lymphocytic choriomeningitis virus infection1. Here we examine the underlying basis for this synergy. We show that PD-1 + IL-2 co...
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Open AccessObesity-induced galectin-9 is a therapeutic target in B-cell acute lymphoblastic leukemia
The incidence of obesity is rising with greater than 40% of the world’s population expected to be overweight or suffering from obesity by 2030. This is alarming because obesity increases mortality rates in pat...
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Targeting BMI-1 in B cells restores effective humoral immune responses and controls chronic viral infection
Ineffective antibody-mediated responses are a key characteristic of chronic viral infection. However, our understanding of the intrinsic mechanisms that drive this dysregulation are unclear. Here, we identify ...
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Open AccessAntibody-secreting cell destiny emerges during the initial stages of B-cell activation
Upon stimulation, B cells assume heterogeneous cell fates, with only a fraction differentiating into antibody-secreting cells (ASC). Here we investigate B cell fate programming and heterogeneity during ASC dif...
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Environmental cues regulate epigenetic reprogramming of airway-resident memory CD8+ T cells
Tissue-resident memory T cells (TRM cells) are critical for cellular immunity to respiratory pathogens and reside in both the airways and the interstitium. In the present study, we found that the airway environme...
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Epigenetic programming underpins B cell dysfunction in human SLE
Systemic lupus erythematosus (SLE) is characterized by the expansion of extrafollicular pathogenic B cells derived from newly activated naive cells. Although these cells express distinct markers, their epigene...
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Open AccessB cell activation and plasma cell differentiation are inhibited by de novo DNA methylation
B cells provide humoral immunity by differentiating into antibody-secreting plasma cells, a process that requires cellular division and is linked to DNA hypomethylation. Conversely, little is known about how d...
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Open AccessPlasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs
The genomic loci associated with B cell differentiation that are subject to transcriptional and epigenetic regulation in vivo are not well defined, leaving a gap in our understanding of the development of humo...
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Plasma cell differentiation is coupled to division-dependent DNA hypomethylation and gene regulation
Boss and colleagues provide mechanistic insight into cell-division-coupled transcriptional and epigenetic reprogramming events during plasma cell differentiation.
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Open AccessATAC-seq on biobanked specimens defines a unique chromatin accessibility structure in naïve SLE B cells
Biobanking is a widespread practice for storing biological samples for future studies ranging from genoty** to RNA analysis. However, methods that probe the status of the epigenome are lacking. Here, the fra...
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Open AccessAurora kinase inhibitors synergize with paclitaxel to induce apoptosis in ovarian cancer cells
A large percentage of patients with recurrent ovarian cancer develop resistance to the taxane class of chemotherapeutics. While mechanisms of resistance are being discovered, novel treatment options and a bett...
