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    Book

    METABIOTICS

    PRESENT STATE, CHALLENGES AND PERSPECTIVES

    Boris A. Shenderov, Alexander V. Sinitsa (2020)

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    Chapter

    Classification of Metabiotics and their Brief Description

    Commercially available metabiotics can be divided according to their composition into dietary supplements, functional and personal foods, therapeutics, cosmetic products (liquid, dry, pastes, creams etc.); pha...

    Boris A. Shenderov, Alexander V. Sinitsa, Mikhail M. Zakharchenko in METABIOTICS (2020)

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    Chapter

    The Composition and Functions of Human Gut Symbiotic Microbiota

    From the contemporary perspective, the human organism should be viewed as the most complex “superorganism”, a symbiotic community of eukaryotic, prokaryotic cells including archaebacteria, and viruses (Ugolev ...

    Boris A. Shenderov, Alexander V. Sinitsa, Mikhail M. Zakharchenko in METABIOTICS (2020)

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    Chapter

    Methods and Techniques Used for Obtaining and Identifying of Microbial Low Molecular Weight Cellular Compounds, Metabolites and Signaling Molecules

    Different techniques and analytical technologies are used for identification of compoundspotentially suitable for constructing various metabiotics. Their choice depends on analytical purposes, qualitative and/...

    Boris A. Shenderov, Alexander V. Sinitsa, Mikhail M. Zakharchenko in METABIOTICS (2020)

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    Chapter

    The Digestive Function of Human Gut Microbiota

    According to the contemporary data, the daily needs of the human organism required for construction and functioning of millions of simple and complex molecular entities amount to over 20 thousand of different ...

    Boris A. Shenderov, Alexander V. Sinitsa, Mikhail M. Zakharchenko in METABIOTICS (2020)

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    Chapter

    Some of the Best-known Metabiotics on the Market of Microecological Products

    In the last decade, some metabiotics have been launched on the markets of a number of countries including the Russian Federation, whose production includes natural (or artificial) bioactive molecules similar o...

    Boris A. Shenderov, Alexander V. Sinitsa, Mikhail M. Zakharchenko in METABIOTICS (2020)

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    Chapter

    Factors and Agents that Modify the Composition and Functions of Symbiotic Microbiota; Diagnostic Methods for Microecological Imbalance and its Consequences

    According to the latest data, human microbiome variability is only by 10% related to individual genetic traits; microbiome differences between individuals are largely associated with the effects of various end...

    Boris A. Shenderov, Alexander V. Sinitsa, Mikhail M. Zakharchenko in METABIOTICS (2020)

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    Chapter

    Prospects in the Field of Intended-Use Metabiotics Creation

    The analysis of contemporary literature bears evidence that the development of therapeutics intended for optimum formation, preservation and restoration of human symbiotic microbiota and their practical implem...

    Boris A. Shenderov, Alexander V. Sinitsa, Mikhail M. Zakharchenko in METABIOTICS (2020)

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    Chapter

    Introduction

    Microorganisms are starters of the nascence and subsequent evolution of all biological life varieties on our planet including humans. A contemporary view of a human organism presents it as a superorganism, a d...

    Boris A. Shenderov, Alexander V. Sinitsa, Mikhail M. Zakharchenko in METABIOTICS (2020)

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    Chapter

    Metabiotics: New Stage of the Probiotic Concept Development

    The knowledge of molecular language of symbiotic (probiotic) microorganisms allows for a more intensive and targeted development of the next generation of probiotics and functional foods. In our opinion, the d...

    Boris A. Shenderov, Alexander V. Sinitsa, Mikhail M. Zakharchenko in METABIOTICS (2020)

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    Chapter

    Contemporary Views on Biotechnological Potential of Symbiotic Microorganisms

    Microorganisms are essentially the main “workhorses” of contemporary biotechnology. It should be noted that a large proportion of microorganism strains existing in nature, including many representatives of ana...

    Boris A. Shenderov, Alexander V. Sinitsa, Mikhail M. Zakharchenko in METABIOTICS (2020)

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    Chapter

    Metabolic Relationship Between the Host and Its Gut Microbiota

    Symbiotic microorganisms ever-present in the organisms of adult people form over 25 thousand different biologically and pharmacologically active compounds. With regard to potential biological effects, the most...

    Boris A. Shenderov, Alexander V. Sinitsa, Mikhail M. Zakharchenko in METABIOTICS (2020)

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    Chapter

    Contemporary Microecological Strategies of Gut Microbiota Modulation for Human Health Preservation, Restoration and Improvement

    For health preservation and reducing the risk of premature ageing and related metabolic diseases, human diet should include various traditional, organic and functional foods as well as therapeutics that suppor...

    Boris A. Shenderov, Alexander V. Sinitsa, Mikhail M. Zakharchenko in METABIOTICS (2020)

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    Chapter

    Drawbacks and Negative Consequences of Traditional Probiotics Based on Live Microorganisms

    The growing market of pharmaceuticals, dietary supplements, and particularly food products based on live probiotic microorganisms, is evidence of their sufficient prophylactic and, if less marked, therapeutic ...

    Boris A. Shenderov, Alexander V. Sinitsa, Mikhail M. Zakharchenko in METABIOTICS (2020)

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    Chapter

    Molecular Language of Symbiotic Gut Microorganisms

    In the 1990s, it was found that various microorganisms, their cell fragments, colloid particles, food starch granules and other compounds similar in size to bacterial cells or smaller can easily penetrate inte...

    Boris A. Shenderov, Alexander V. Sinitsa, Mikhail M. Zakharchenko in METABIOTICS (2020)

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    Chapter

    Conclusion

    As regards cell quantitative content, a human being is essentially a more prokaryotic than eukaryotic organism. Great success has been achieved in the characterization of microorganisms inhabiting the human be...

    Boris A. Shenderov, Alexander V. Sinitsa, Mikhail M. Zakharchenko in METABIOTICS (2020)

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    Chapter

    Cellular Metabiotics and Metabolite Metabiotics

    To provide a clearer picture of what modern techniques and technologies are used when develo** metabiotics and launching them on the market of therapeutics and functional foods, let us describe how metabioti...

    Boris A. Shenderov, Alexander V. Sinitsa, Mikhail M. Zakharchenko in METABIOTICS (2020)

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    Chapter

    Some New Targets and Approaches to the Construction of Intended-Use Metabiotics

    Tables 1, 2, 3, 4, 5, 6, 7 and 8 show some new targets and approaches to the use of low molecular microbial molecules for the development and production of essentially new metabiotics in order to prevent and t...

    Boris A. Shenderov, Alexander V. Sinitsa, Mikhail M. Zakharchenko in METABIOTICS (2020)

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    Article

    Subversion of innate and adaptive immune responses by Toxoplasma Gondii

    The intracellular apicomplexan parasite Toxoplasma gondii is able to survive and persist in immunocompetent intermediate hosts for the host’s life span. This is despite the induction of a vigorous humoral and—mor...

    Christine Lang, Uwe Groß, Carsten G. K. Lüder in Parasitology Research (2007)

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    Article

    Intracellular transport of a heterologous membrane protein, the human transferrin receptor, in Saccharomyces cerevisiae

    We have analyzed the intracellular behavior of the human transferrin receptor (TfR) in Saccharomyces cerevisiae. The major part of the heterologously expressed TfR, which has previously been used as a model for h...

    Bianka Prinz, Ulf Stahl, Christine Lang in International Microbiology (2003)