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  1. No Access

    Article

    Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation

    Umami refers to the savoury taste that is mediated by monosodium glutamate (MSG) and enhanced by inosine monophosphate and other nucleotides. Umami foods have been suggested to increase the risk for obesity an...

    Ana Andres-Hernando, Christina Cicerchi, Masanari Kuwabara… in Nature Metabolism (2021)

  2. Article

    Open Access

    Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice

    Acute kidney injury is associated with high mortality, especially in intensive care unit patients. The polyol pathway is a metabolic route able to convert glucose into fructose. Here we show the detrimental ro...

    Ana Andres-Hernando, Nanxing Li, Christina Cicerchi… in Nature Communications (2017)

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  3. Article

    Correction: Corrigendum: Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome

    Nature Communications 4: Article number: 2434 (2013); Published: 10 September 2013; Updated: 4 December 2013 The original version of this Article contained an error in the spelling of the author Philip Ruzycki...

    Miguel A. Lanaspa, Takuji Ishimoto, Nanxing Li, Christina Cicerchi… in Nature Communications (2013)

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  4. No Access

    Article

    Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome

    Carbohydrates with high glycaemic index are proposed to promote the development of obesity, insulin resistance and fatty liver, but the mechanism by which this occurs remains unknown. High serum glucose concen...

    Miguel A. Lanaspa, Takuji Ishimoto, Nanxing Li, Christina Cicerchi… in Nature Communications (2013)