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Article
Open AccessSignal strength of STING activation determines cytokine plasticity and cell death in human monocytes
The cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway is a cytosolic sensor of microbial and host-derived DNA and plays a key role in innate immunity. Activation of STING by cyclic ...
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Article
Open AccessVitamin C and Vitamin D—friends or foes in modulating γδ T-cell differentiation?
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Article
Open AccessMonocyte-dependent co-stimulation of cytokine induction in human γδ T cells by TLR8 RNA ligands
Human Vγ9Vδ2 T cells recognize pyrophosphates produced by microbes and transformed cells and play a role in anti-infective immunity and tumor surveillance. Toll-like receptors (TLR) are pattern recognition rec...
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Article
Open AccessReply to: Vitamin C as a promoter of γδ T cells
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Article
Open AccessAllogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer
Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy. Due to their HLA-independent mode of action, allogeneic Vγ9Vδ2 T cells can be considered for clinical application. To apply allogeneic ...
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Article
Open AccessCorrection to: Cancer immunotherapy with γδ T cells: many paths ahead of us
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessCancer immunotherapy with γδ T cells: many paths ahead of us
γδ T cells play uniquely important roles in stress surveillance and immunity for infections and carcinogenesis. Human γδ T cells recognize and kill transformed cells independently of human leukocyte antigen (H...
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Article
Open AccessVitamin C promotes the proliferation and effector functions of human γδ T cells
γδ T cells are of interest as effector cells for cellular immunotherapy due to their HLA-non-restricted lysis of many different tumor cell types. Potential applications include the adoptive transfer of in vitr...
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Article
Open AccessVitamin C supports conversion of human γδ T cells into FOXP3-expressing regulatory cells by epigenetic regulation
Human γδ T cells are potent cytotoxic effector cells, produce a variety of cytokines, and can acquire regulatory activity. Induction of FOXP3, the key transcription factor of regulatory T cells (Treg), by TGF-...
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Article
Degranulation of human cytotoxic lymphocytes is a major source of proteolytically active soluble CD26/DPP4
Dipeptidyl peptidase 4 (DPP4, CD26) is a serine protease detected on several immune cells and on epithelial cells of various organs. Besides the membrane-bound enzyme, a catalytically active soluble form (sCD2...
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Article
Regulatory functions of γδ T cells
γδ T cells share characteristics of innate and adaptive immune cells and are involved in a broad spectrum of pro-inflammatory functions. Nonetheless, there is accumulating evidence that γδ T cells also exhibit...
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Chapter and Conference Paper
Ökologische Stadtreparatur am Venusberg – Kombination aus Umnutzung und Niedrigenergiebauweise
Ein leerstehender und zunehmend verfallender Gebäudekomplex aus den 1890er Jahren, bestehend aus ehemaligen Stall- und Remisengebäuden eines Fuhrwagenbetriebes, soll für eine erneute Nutzung vollständig umgest...
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Article
Open AccessPhenotype and regulation of immunosuppressive Vδ2-expressing γδ T cells
The proliferation and interleukin-2 production of CD4+CD25− αβ T cells were inhibited in a cell-contact manner by Vδ2 γδ T cells. The transcription factor Helios was constitutively expressed in about one-third of...
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Chapter and Conference Paper
TEBRA: Automatic Task Assistance for Persons with Cognitive Disabilities in Brushing Teeth
We introduce a novel Assistive Technology for Cognition. The TEBRA system assists persons with cognitive disabilities in brushing teeth by prompting the user. We develop the system based on an analysis of the ...
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Article
Superparamagnetic microrobots: fabrication by two-photon polymerization and biocompatibility
This work presents the fabrication and controlled actuation of swimming microrobots made of a magnetic polymer composite (MPC) consisting of 11-nm-diameter magnetite (Fe3O4) nanoparticles and photocurable resin (...
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Article
Modulation of γδ T cell responses by TLR ligands
Toll-like receptors (TLR) are pattern-recognition receptors that recognize a broad variety of structurally conserved molecules derived from microbes. The recognition of TLR ligands functions as a primary senso...
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Chapter
Brenz, Johannes
B. war Reformator der Reichsstadt Schwäbisch Hall, wichtigster Gewährsmann Martin Luthers in Südwestdeutschland und treibende Kraft beim Wiederaufbau der evangelischen Kirche des Herzogtums Württemberg nach de...
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Chapter
Einkaufsplattformen als Sourcing-Alternativen für den pharmazeutischen Mittelstand: das Beispiel pharmaplace. de
Die zunehmende Verbreitung des Internet sowohl im privaten als insbesondere auch im geschäftlichen Umfeld hat einschneidende Veränderungen im Arbeitsalltag induziert. So wurden beispielsweise die „klassischen“...
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Chapter and Conference Paper
Fracture Properties of LPCVD Silicon Nitride Thin Films from the Load-Deflection of Long Membranes
The bulge test is successfully extended to the determination of the fracture strength of thin films by accurately describing the deflection profile of the loaded long membranes. The model includes the prestres...
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Chapter
Artikel A–Z
