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Polar Constituent of the Endophytic Fungus Ophiocordyceps sobolifera
Fractionation of the n-BuOH-soluble fraction of the liquid fermentation of the endophytic fungus Ophiocordyceps sobolifera associated with the root of Taiwanese Ilex formosana (Aquifoliaceae) resulted in the i...
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Open AccessLobohedleolide suppresses hepatitis C virus replication via JNK/c-Jun-C/EBP-mediated down-regulation of cyclooxygenase-2 expression
Hepatitis C virus (HCV) chronically infects 2–3% people of the global population, which leads to liver cirrhosis and hepatocellular carcinoma. Drug resistance remains a serious problem that limits the effectiv...
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Open AccessCyclooxygenase‐2 facilitates dengue virus replication and serves as a potential target for develo** antiviral agents
Cyclooxygenase-2 (COX-2) is one of the important mediators of inflammation in response to viral infection, and it contributes to viral replication, for example, cytomegalovirus or hepatitis C virus replication...
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Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking
GNPS is an open-access community-curated analysis platform for sharing natural product mass spectrometry data that enables continuous, automatic reanalysis of deposited 'living' data sets.
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Acetogenins from Annonaceae
In recent decades, annonaceous acetogenins have become highly studied plant secondary metabolites in terms of their isolation, structure elucidation, synthesis, biological evaluation, mechanism of action, and ...
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Activation and Inhibition of ATM by Phytochemicals: Awakening and Slee** the Guardian Angel Naturally
Double-stranded breaks (DSBs) are cytotoxic DNA lesions caused by oxygen radicals, ionizing radiation, and radiomimetic chemicals. Increasing understanding of DNA damage signaling has provided an ever-expandin...
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Open AccessVitroprocines, new antibiotics against Acinetobacter baumannii, discovered from marine Vibrio sp. QWI-06 using mass-spectrometry-based metabolomics approach
A robust and convenient research strategy integrating state-of-the-art analytical techniques is needed to efficiently discover novel compounds from marine microbial resources. In this study, we identified a se...
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Open AccessAnticancer drugs for the modulation of endoplasmic reticulum stress and oxidative stress
Prior research has demonstrated how the endoplasmic reticulum (ER) functions as a multifunctional organelle and as a well-orchestrated protein-folding unit. It consists of sensors which detect stress-induced u...
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Neuroprotective Effects of Ugonin K on Hydrogen Peroxide-Induced Cell Death in Human Neuroblastoma SH-SY5Y Cells
Oxidative stress plays an important role in the pathological processes of various neurodegenerative diseases. Ugonin K, a flavonoid isolated from the rhizomes of Helminthostachys zeylanica, possesses potent antio...
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Chemical constituents from theHydrangea chinensis
Two quinazolone alkaloids, (+)-febrifugine (1) and isofebrifugine (2), along with three coumarin derivatives, 6-hydroxy coumarin (3), skimmin (5), and umbelliferone-7-O-α-L-rhamnopyranosyl(1→4)-β-D-glucopyranosid...
