33 Result(s)

Article

Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement

Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroida...

Mayumi Ueta, Nahoko Kaniwa, Chie Sotozono, Katsushi Tokunaga… in Scientific Reports (2014)

Article

Strong association between hla-a*02:06 and acetaminophen-related stevens-johnson syndrome with severe mucosal involvements in the Japanese

Mayumi Ueta, Chie Sotozono, Hiromi Sawai… in Clinical and Translational Allergy (2014)

Article

Medication tendencies for inducing severe ocular surface symptoms in Japanese Stevens-Johnson Syndrome / toxic epidermal necrolysis patients

Yoshiro Saito, Mayumi Ueta, Ryosuke Nakamura… in Clinical and Translational Allergy (2014)

Article

HLA association with antipyretic analgesics-induced Stevens-Johnson Syndrome/toxic epidermal necrolysis with severe ocular surface complications in japanese patients

Ryosuke Nakamura, Nahoko Kaniwa, Mayumi Ueta… in Clinical and Translational Allergy (2014)

Article

Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications

Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroida...

Mayumi Ueta, Chitra Kannabiran, Tais Hitomi Wakamatsu, Mee Kum Kim… in Scientific Reports (2014)

Article

Downregulation of IL-8, ECP, and total IgE in the tears of patients with atopic keratoconjunctivitis treated with rebamipide eyedrops

Rebamipide eyedrops are approved in Japan for the treatment of dry eye disease. Some patients with allergic conjunctival diseases also manifest dry eye. Earlier we reported that rebamipide suppressed polyI:C-i...

Mayumi Ueta, Jun Shoji, Chie Sotozono… in Clinical and Translational Allergy (2014)

Article

HLA-A*02:06 and PTGER3 polymorphism exert additive effects in cold medicine-related Stevens–Johnson syndrome with severe ocular complications

We previously reported that PTGER3 (prostaglandin E receptor 3 (subtype EP3)) single-nucleotide polymorphisms (SNPs) were associated with Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with sever...

Mayumi Ueta, Katsushi Tokunaga, Chie Sotozono, Hiromi Sawai… in Human Genome Variation (2015)

Article

Elevated expression of ABCB5 in ocular surface squamous neoplasia

ATP-binding cassette subfamily B member 5 (ABCB5) is a new member of the ATP-binding cassette superfamily and has been reported as a novel marker for limbal stem cell (LSC), which is essential for corneal home...

Passara Jongkhajornpong, Takahiro Nakamura, Chie Sotozono… in Scientific Reports (2016)

Article

7th Drug hypersensitivity meeting: part two

Poster walk 11: miscellaneous drug hypersensitivity 2 (P92–P94, P96–P101)

Javier Dionicio Elera, Cosmin Boteanu… in Clinical and Translational Allergy (2016)

Article

Development of functional human oral mucosal epithelial stem/progenitor cell sheets using a feeder-free and serum-free culture system for ocular surface reconstruction

Ocular surface reconstruction (OSR) using tissue-engineered cultivated oral mucosal epithelial cell sheets (COMECS) is a promising newly developed treatment for patients with severe ocular surface disease. Unt...

Takahiro Nakamura, Seiichi Yokoo, Adams J. Bentley, Maho Nagata… in Scientific Reports (2016)

Article

Efficient and reliable establishment of lymphoblastoid cell lines by Epstein-Barr virus transformation from a limited amount of peripheral blood

Lymphoblastoid cell lines (LCLs) transformed by Epstein-Barr virus (EBV) serve as an unlimited resource of human genomic DNA. The protocol that is widely used to establish LCLs involves peripheral blood mononu...

Natsue Omi, Yuichi Tokuda, Yoko Ikeda, Morio Ueno, Kazuhiko Mori… in Scientific Reports (2017)

Article

Predictive clinical factors of cystoid macular edema in patients with Descemet’s strip** automated endothelial keratoplasty

The purpose of this present study was to investigate predictive clinical factors associated with cystoid macular edema (CME) post Descemet’s strip** automated endothelial keratoplasty (DSAEK) in a large case...

Koji Kitazawa, Kanae Kayukawa, Koichi Wakimasu, Isao Yokota… in Scientific Reports (2017)

Article

Immunohistochemical Detection of Propionibacterium acnes in the Retinal Granulomas in Patients with Ocular Sarcoidosis

The etiology of sarcoidosis is still obscure; however, Mycobacteria and Propionibacterium acnes are considered the most implicated etiological agent for sarcoidosis. To investigate whether P. acnes is an etiologi...

Kenji Nagata, Yoshinobu Eishi, Keisuke Uchida, Kazuhito Yoneda… in Scientific Reports (2017)

Article

Distinct Aqueous Humour Cytokine Profiles of Patients with Pachychoroid Neovasculopathy and Neovascular Age-related Macular Degeneration

This study investigated the pathophysiological features of pachychoroid neovasculopathy (PNV) and neovascular age-related macular degeneration (nAMD) by analysing and comparing cytokine profiles in aqueous hum...

Nobuhiro Terao, Hideki Koizumi, Kentaro Kojima, Tetsuya Yamagishi… in Scientific Reports (2018)

Article

Involvement of anterior and posterior corneal surface area imbalance in the pathological change of keratoconus

Keratoconus (KC) is an ectatic disorder with a high prevalence rate. However, the exact cause of the disease and possible underlying mechanisms of development remain unclear. In this present study, we aimed to...

Koji Kitazawa, Motohiro Itoi, Isao Yokota, Koichi Wakimasu, Yuko Cho… in Scientific Reports (2018)

Article

Association of HLA class I and II gene polymorphisms with acetaminophen-related Stevens–Johnson syndrome with severe ocular complications in Japanese individuals

Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute-onset mucocutaneous diseases induced by infectious agents and/or inciting drugs. We have reported that the main causative drugs for...

Mayumi Ueta, Ryosuke Nakamura, Yoshiro Saito, Katsushi Tokunaga… in Human Genome Variation (2019)

Article

Identification of HLA-A*02:06:01 as the primary disease susceptibility HLA allele in cold medicine-related Stevens-Johnson syndrome with severe ocular complications by high-resolution NGS-based HLA ty**

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening acute inflammatory vesiculobullous reactions of the skin and mucous membranes. These severe cutaneous drug reactions are...

Ken Nakatani, Mayumi Ueta, Seik-Soon Khor, Yuki Hitomi, Yuko Okudaira… in Scientific Reports (2019)

Article

Rebamipide promotes lacrimal duct epithelial cell survival via protecting barrier function

Nasolacrimal duct obstruction (NLDO) is thought to be due to inflammation and fibrosis of lacrimal duct epithelial cells (LDECs). Here we investigated the effect of rebamipide, a drug that is used for the prot...

Hiroshi Tanaka, Tomomichi Nakayama, Michiko Tsukamoto… in Scientific Reports (2020)

Article

Evaluation of pre- and post-surgery reading ability in patients with epiretinal membrane: a prospective observational study

This study aimed to investigate the pre- and post-surgery reading ability in patients with idiopathic epiretinal membrane (ERM) to evaluate whether measurement of reading performance is a helpful test in addit...

Hiroki Mieno, Kentaro Kojima, Kazuhito Yoneda, Fumie Kinoshita… in BMC Ophthalmology (2020)

Article

Risk Factors for Corneal Endothelial Cell Loss in Patients with Pseudoexfoliation Syndrome

This study investigated corneal endothelial cell density (ECD) in pseudoexfoliation (PEX) syndrome patients and evaluated the clinical factors associated with ECD for 51 eyes of 41 phakic patients with pseudoe...

Takanori Aoki, Koji Kitazawa, Tsutomu Inatomi, Natsuki Kusada… in Scientific Reports (2020)