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  1. Article

    Open Access

    The clinical characteristics and therapeutic outcomes of adult patients with community-acquired spontaneous bacterial meningitis with a fulminant clinical course in Taiwan

    To examine the clinical characteristics of adult patients with community-acquired spontaneous bacterial meningitis (CASBM) with a fulminant clinical course.

    Chia-Yi Lien, Chun-Chih Chien, Cheng-Hsien Lu, Wen-Neng Chang in BMC Infectious Diseases (2023)

  2. Article

    Open Access

    ABCA7 polymorphisms correlate with memory impairment and default mode network in patients with APOEε4-associated Alzheimer’s disease

    Since both APOE and ABCA7 protein expression may independently reduce neuritic plaque burden and reorganize fibrillar amyloid burden-mediated disruption of functional connectivity in the default mode network, we ...

    Ya-Ting Chang, Shih-Wei Hsu, Shu-Hua Huang, Chi-Wei Huang in Alzheimer's Research & Therapy (2019)

  3. No Access

    Article

    MAOA-VNTR Genotype Effects on Ventral Striatum-Hippocampus Network in Alzheimer’s Disease: Analysis Using Structural Covariance Network and Correlation with Neurobehavior Performance

    Functional polymorphisms in the promoter region of the monoamine oxidase A (MAOA) gene are associated with brain MAOA activity and transcriptional efficiency in patients with Alzheimer’s disease (AD). This study ...

    Hsin-I Chang, Ya-Ting Chang, Shih-Jen Tsai, Chi-Wei Huang in Molecular Neurobiology (2019)

  4. Article

    Open Access

    The clinical characteristics and therapeutic outcomes of cryptococcal meningitis in elderly patients: a hospital-based study

    The elderly, and especially those with an immuno-compromised status, are vulnerable to infectious diseases. The purpose of this study was to examine the clinical characteristics and therapeutic outcomes of cry...

    Wan-Chen Tsai, Chia-Yi Lien, Jun-Jun Lee, Wen-Chiu Hsiao, Chi-Ren Huang in BMC Geriatrics (2019)

  5. Article

    Open Access

    Associations of Bcl-2 rs956572 genotype groups in the structural covariance network in early-stage Alzheimer’s disease

    Alzheimer’s disease (AD) is a complex neurodegenerative disease, and genetic differences may mediate neuronal degeneration. In humans, a single-nucleotide polymorphism in the B-cell chronic lymphocytic leukemi...

    Chiung-Chih Chang, Ya-Ting Chang, Chi-Wei Huang in Alzheimer's Research & Therapy (2018)