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    Microenvironment Triggers EMT, Migration and Invasion of Primary Tumor via Multiple Signal Pathways

    In the tumor microenvironment, the primary tumor cells may recruit and interact with stromal cells and inflammatory cells including macrophages, mast cells and neutrophiles. A great multitude of growth factors...

    Wen-Sheng Wu, Chi-Tan Hu in Signal Transduction in Cancer Metastasis (2010)

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    Signal Cross Talks for Sustained MAPK Activation and Cell Migration Mediated by Reactive Oxygen Species: The Involvement in Tumor Progression

    Signal transduction exerted by the microenvironment around the primary tumor locus may trigger tumor metastasis especially at the migration stage. Sustained mitogen activated protein kinase (MAPK) signaling in...

    Chi-Tan Hu, Jia-Ru Wu, Wen-Sheng Wu in Signal Transduction in Cancer Metastasis (2010)