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Article
Open AccessFrizzled class receptor 5 contributes to ovarian cancer chemoresistance through aldehyde dehydrogenase 1A1
Chemoresistance is associated with tumor relapse and unfavorable prognosis. Multiple mechanisms underlying chemoresistance have been elucidated, including stemness and DNA damage repair. Here, the involvement ...
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Article
Open AccessYTHDF1 promotes breast cancer cell growth, DNA damage repair and chemoresistance
Chemoresistance represents a major obstacle to the treatment of human cancers. Increased DNA repair capacity is one of the important mechanisms underlying chemoresistance. In silico analysis indicated that YTHDF1...
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Article
Open AccessEMP3 negatively modulates breast cancer cell DNA replication, DNA damage repair, and stem-like properties
Enhanced DNA damage repair capacity attenuates cell killing of DNA-damaging chemotherapeutic agents. In silico analysis showed that epithelial membrane protein 3 (EMP3) is associated with favorable survival, a...
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Article
Open AccessFZD5 prevents epithelial-mesenchymal transition in gastric cancer
Frizzled (FZD) proteins function as receptors for WNT ligands. Members in FZD family including FZD2, FZD4, FZD7, FZD8 and FZD10 have been demonstrated to mediate cancer cell epithelial-mesenchymal transition (...
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Article
Open AccessFZD5 contributes to TNBC proliferation, DNA damage repair and stemness
Chemotherapy currently remains the standard treatment for triple-negative breast cancer (TNBC). However, TNBC frequently develop chemoresistance, which is responsible for cancer recurrence and distal metastasi...
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Article
Open AccessNon-canonical Fzd7 signaling contributes to breast cancer mesenchymal-like stemness involving Col6a1
Mesenchymal-like stemness is characterized by epithelial-mesenchymal transition (EMT). Breast cancer (BC) cell mesenchymal-like stemness is responsible for distal lung metastasis. Interrogation of databases sh...
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Article
In-situ sulfur isotope and trace element of pyrite constraints on the formation and evolution of the Nibao Carlin-type gold deposit in SW China
The fault-controlled Nibao Carlin-type gold deposit, together with the strata-bound Shuiyindong deposit, comprise a significant amount of the disseminated gold deposits in southwestern Guizhou Province, China....
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Article
Open AccessCD155 downregulation synergizes with adriamycin to induce breast cancer cell apoptosis
CD155 has been implicated in migration, invasion, proliferation and apoptosis of human cancer cells, and DNA damage response caused by chemotherapeutic agents or reactive oxygen species has been shown to attri...
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Article
Open AccessZFAS1: a novel tumor-related long non-coding RNA
Long non-coding RNAs (lncRNA) are classified as a kind of RNA, which are longer than 200 nucleotides in length and cannot be translated into proteins. Multiple studies have demonstrated that lncRNAs are involv...
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Article
Live kinase B1 maintains CD34+CD38− AML cell proliferation and self-renewal
Live kinase B1 (LKB1) has been recognized as a tumor suppressor in many human cancers; however, LKB1 maintains self-renewal of hematopoietic stem cells (HSCs). The existence of leukemia stem cells (LSCs) is re...
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Article
Open AccessIL-1β mediates MCP-1 induction by Wnt5a in gastric cancer cells
Both Wnt5a overexpression and macrophage infiltration have been implicated in inflammation and cancer. The aim of this study is to reveal the involvement of Wnt5a in macrophage recruitment in gastric cancer.
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Article
Significant association between GSTT1 null genotype and susceptibility to pancreatic cancer
Many studies have investigated the association between glutathione S-transferase T1 (GSTT1) polymorphism and risk for pancreatic cancer, but those studies have yielded contradictory findings on the association. W...
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Article
The association between cyclooxygenase-2 1195 G/A polymorphism and hepatocellular carcinoma: evidence from a meta-analysis
Cyclooxygenase-2 (COX-2) is proven to influence the carcinogenesis through immune response suppression, apoptosis inhibition, angiogenesis regulation, and tumor cell invasion. Previous studies assessing the as...
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Article
Open AccessWnt5a promotes ewing sarcoma cell migration through upregulating CXCR4 expression
As one of the malignant tumors most often affecting children and young adults, Ewing sarcoma (ES) is characterized by early metastasis contributing to unfavorable prognosis. However, the molecular mechanisms r...
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Article
Open AccessInvolvement of tumor necrosis factor-α in the upregulation of CXCR4 expression in gastric cancer induced by Helicobacter pylori
H. pylori, whose infection increases tumor invasiveness and metastasis, is generally labelled as the strongest risk factor for the development of gastric cancer. It appears not to be a coincidence that there i...
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Article
Open AccessDownregulation of SFRP5 expression and its inverse correlation with those of MMP-7 and MT1-MMP in gastric cancer
As negative regulators in Wnt signaling, Secreted Frizzled-Related Proteins (SFRPs) are downregulated in a series of human cancers; and specifically, some matrix metalloproteinases (MMPs), including MMP-2, MMP...
