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    Article

    MYPT1SMKO Mice Function as a Novel Spontaneous Age- and Hypertension-Dependent Animal Model of CSVD

    Cerebral small vessel disease (CSVD) is the most common progressive vascular disease that causes vascular dementia. Aging and hypertension are major contributors to CSVD, but the pathophysiological mechanism r...

    Jian Chen, Cheng-Gang Li, Li-Xuan Yang, Yi Qian… in Translational Stroke Research (2024)

  2. Article

    Dicer1/miR-29/HMGCR axis contributes to hepatic free cholesterol accumulation in mouse non-alcoholic steatohepatitis

    Dicer1 is an enzyme essential for microRNA (miRNA) maturation. The loss of miRNAs resulted from Dicer1 deficiency greatly contributes to the progression of many diseases, including lipid dysregulation, but its ro...

    Ming-xia Liu, Man Gao, Chun-zhu Li, Cun-zhi Yu, Hong Yan… in Acta Pharmacologica Sinica (2017)

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  3. Article

    MicroRNA-1304 suppresses human non-small cell lung cancer cell growth in vitro by targeting heme oxygenase-1

    Previous studies have shown that microRNA-1304 (miR-1304) is dysregulated in certain types of cancers, including non-small cell lung cancer (NSCLC), and might be involved in tumor survival and/or growth. In th...

    Cheng-gang Li, Meng-fan Pu, Chun-zhu Li, Man Gao… in Acta Pharmacologica Sinica (2017)

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  4. Article

    Hepatic cytochrome P450s play a major role in monocrotaline-induced renal toxicity in mice

    Monocrotaline (MCT) in plants of the genus Crotalaria induces significant toxicity in multiple organs including the liver, lung and kidney. Metabolic activation of MCT is required for MCT-induced toxicity. In thi...

    Jun Yao, Cheng-gang Li, Li-kun Gong, Chen-chen Feng… in Acta Pharmacologica Sinica (2014)

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